| H00023 | |
| H number | H00023 |
| Name | Testicular cancer |
| Description | Testicular germ cell tumor (TGCT) comprises about 98% of all testicular neoplasms and is thereby the most common malignancy among young males. Overall, three different entities of TGCT can be distinguished: teratomas and yolk sac tumors of newborns and infants, seminomatous and nonseminomatous germ cell tumors of adolescents and young adults, and spermatocytic seminoma of elderly men. Recent studies of TGCTs have suggested that overexpression of cyclin D2 is a very early, possibly the oncogenic, event in GC tumorigenesis. |
| Category | Cancer |
| Network | - |
| Gene | CCND2 (amplification) [HSA:894] [KO:K10151] FGFR3 [HSA:2261] [KO:K05094] KIT [HSA:3815] [KO:K05091] STK11 [HSA:6794] [KO:K07298] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Ifosfamide [DR:D00343] Vinblastine sulfate [DR:D01068] Etoposide [DR:D00125] Etoposide phosphate [DR:D04107] Dactinomycin [DR:D00214] Bleomycin sulfate [DR:D02177] Cisplatin [DR:D00275] |
| Comment | - |
| Other DBs | ICD-11: 2C80 ICD-10: C62 MeSH: D013736 OMIM: 273300 |
| Reference | PMID:18042148 AUTHORS Lind GE, Skotheim RI, Lothe RA TITLE The epigenome of testicular germ cell tumors. JOURNAL APMIS 115:1147-60 (2007) DOI:10.1111/j.1600-0463.2007.apm_660.xml.x PMID:10749107 AUTHORS Chaganti RS, Houldsworth J. TITLE Genetics and biology of adult human male germ cell tumors. JOURNAL Cancer Res 60:1475-82 (2000) PMID:9791864 AUTHORS Lutzker SG, Barnard NJ. TITLE Testicular germ cell tumors: molecular understanding and clinical implications. JOURNAL Mol Med Today 4:404-11 (1998) DOI:10.1016/S1357-4310(98)01329-X PMID:17683189 AUTHORS Bahrami A, Ro JY, Ayala AG. TITLE An overview of testicular germ cell tumors. JOURNAL Arch Pathol Lab Med 131:1267-80 (2007) DOI:10.1043/1543-2165(2007)131[1267:AOOTGC]2.0.CO;2 PMID:9056671 (CCND2) AUTHORS Houldsworth J, Reuter V, Bosl GJ, Chaganti RS TITLE Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis. JOURNAL Cell Growth Differ 8:293-9 (1997) PMID:19855393 (FGFR3) AUTHORS Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Rajpert-De Meyts E, Wilkie AO TITLE Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. JOURNAL Nat Genet 41:1247-52 (2009) DOI:10.1038/ng.470 PMID:10362788 (KIT) AUTHORS Tian Q, Frierson HF Jr, Krystal GW, Moskaluk CA TITLE Activating c-kit gene mutations in human germ cell tumors. JOURNAL Am J Pathol 154:1643-7 (1999) DOI:10.1016/S0002-9440(10)65419-3 PMID:9605748 (STK11) AUTHORS Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE, Fossa SD, Salovaara R, Aaltonen LA TITLE Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. JOURNAL Cancer Res 58:2087-90 (1998) |