| H00344 | |
| H番号 | H00344 |
| 名称 | ハンセン病 |
| 概要 | Leprosy, also called Hansen's disease, is a chronic infection caused by Mycobacterium leprae (M. leprae) and the more recently discovered Mycobacterium lepromatosis (M. lepromatosis). It primarily affects peripheral nerves, skin and mucosa particularly the upper respiratory tract. |
| カテゴリ | 細菌感染症 |
| ネットワーク | nt06517(H00344) TLR signaling |
| 病因遺伝子 | (LPRS3) TLR2 (polymorphism) [HSA:7097] [KO:K10159] (LPRS4) LTA (polymorphism) [HSA:4049] [KO:K05468] (LPRS5) TLR1 (polymorphism) [HSA:7096] [KO:K05398] PRKN (polymorphism) [HSA:5071] [KO:K04556] HLA [HSA:3105 3106 3107 3133 3134 3135] [KO:K06751] |
| 病原体 | Mycobacterium leprae [GN:mle] (from India) Mycobacterium leprae [GN:mlb] (from Brazil) Mycobacterium lepromatosis [GN:mlm] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | オフロキサシン [DR:D00453] ジアフェニルスルホン [DR:D00592] リファンピシン [DR:D00211] クロファジミン [DR:D00278] |
| コメント | - |
| リンク | ICD-11: 1B20 ICD-10: A30 MeSH: D007918 OMIM: 613223 246300 610988 607572 609888 MedlinePlus: 001347 |
| 文献 | PMID:21616456 著者 Rodrigues LC, Lockwood DNj タイトル Leprosy now: epidemiology, progress, challenges, and research gaps. 雑誌 Lancet Infect Dis 11:464-70 (2011) DOI:10.1016/S1473-3099(11)70006-8 PMID:32339201 著者 Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T タイトル Reservoirs and transmission routes of leprosy; A systematic review. 雑誌 PLoS Negl Trop Dis 14:e0008276 (2020) DOI:10.1371/journal.pntd.0008276 PMID:15726416 (TLR2) 著者 Malhotra D, Relhan V, Reddy BS, Bamezai R タイトル TLR2 Arg677Trp polymorphism in leprosy: revisited. 雑誌 Hum Genet 116:413-5 (2005) DOI:10.1007/s00439-004-1249-9 PMID:17353895 (LTA) 著者 Alcais A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M, Vanderborght PR, Katoch K, Mira MT, Vu HT, Ngyuen TH, Nguyen NB, Moraes M, Mehra N, Schurr E, Abel L タイトル Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy. 雑誌 Nat Genet 39:517-22 (2007) DOI:10.1038/ng2000 PMID:17548585 (TLR1) 著者 Johnson CM, Lyle EA, Omueti KO, Stepensky VA, Yegin O, Alpsoy E, Hamann L, Schumann RR, Tapping RI タイトル Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. 雑誌 J Immunol 178:7520-4 (2007) DOI:10.4049/jimmunol.178.12.7520 PMID:14737177 (PRKN) 著者 Mira MT, Alcais A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Dore C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E タイトル Susceptibility to leprosy is associated with PARK2 and PACRG. 雑誌 Nature 427:636-40 (2004) DOI:10.1038/nature02326 PMID:16728267 (HLA) 著者 Geluk A, Ottenhoff TH タイトル HLA and leprosy in the pre and postgenomic eras. 雑誌 Hum Immunol 67:439-45 (2006) DOI:10.1016/j.humimm.2006.03.009 |