H00344 | |
H number | H00344 |
Name | Leprosy; Hansen disease |
Description | Leprosy, also called Hansen's disease, is a chronic infection caused by Mycobacterium leprae (M. leprae) and the more recently discovered Mycobacterium lepromatosis (M. lepromatosis). It primarily affects peripheral nerves, skin and mucosa particularly the upper respiratory tract. |
Category | Bacterial infectious disease |
Network | nt06517(H00344) TLR signaling |
Gene | (LPRS3) TLR2 (polymorphism) [HSA:7097] [KO:K10159] (LPRS4) LTA (polymorphism) [HSA:4049] [KO:K05468] (LPRS5) TLR1 (polymorphism) [HSA:7096] [KO:K05398] PRKN (polymorphism) [HSA:5071] [KO:K04556] HLA [HSA:3105 3106 3107 3133 3134 3135] [KO:K06751] |
Pathogen | Mycobacterium leprae [GN:mle] (from India) Mycobacterium leprae [GN:mlb] (from Brazil) Mycobacterium lepromatosis [GN:mlm] |
Env factor | - |
Carcinogen | - |
Drug | Dapsone [DR:D00592] |
Comment | - |
Other DBs | ICD-11: 1B20 ICD-10: A30 MeSH: D007918 OMIM: 613223 246300 610988 607572 609888 MedlinePlus: 001347 |
Reference | PMID:21616456 AUTHORS Rodrigues LC, Lockwood DNj TITLE Leprosy now: epidemiology, progress, challenges, and research gaps. JOURNAL Lancet Infect Dis 11:464-70 (2011) DOI:10.1016/S1473-3099(11)70006-8 PMID:32339201 AUTHORS Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T TITLE Reservoirs and transmission routes of leprosy; A systematic review. JOURNAL PLoS Negl Trop Dis 14:e0008276 (2020) DOI:10.1371/journal.pntd.0008276 PMID:15726416 (TLR2) AUTHORS Malhotra D, Relhan V, Reddy BS, Bamezai R TITLE TLR2 Arg677Trp polymorphism in leprosy: revisited. JOURNAL Hum Genet 116:413-5 (2005) DOI:10.1007/s00439-004-1249-9 PMID:17353895 (LTA) AUTHORS Alcais A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M, Vanderborght PR, Katoch K, Mira MT, Vu HT, Ngyuen TH, Nguyen NB, Moraes M, Mehra N, Schurr E, Abel L TITLE Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy. JOURNAL Nat Genet 39:517-22 (2007) DOI:10.1038/ng2000 PMID:17548585 (TLR1) AUTHORS Johnson CM, Lyle EA, Omueti KO, Stepensky VA, Yegin O, Alpsoy E, Hamann L, Schumann RR, Tapping RI TITLE Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. JOURNAL J Immunol 178:7520-4 (2007) DOI:10.4049/jimmunol.178.12.7520 PMID:14737177 (PRKN) AUTHORS Mira MT, Alcais A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Dore C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E TITLE Susceptibility to leprosy is associated with PARK2 and PACRG. JOURNAL Nature 427:636-40 (2004) DOI:10.1038/nature02326 PMID:16728267 (HLA) AUTHORS Geluk A, Ottenhoff TH TITLE HLA and leprosy in the pre and postgenomic eras. JOURNAL Hum Immunol 67:439-45 (2006) DOI:10.1016/j.humimm.2006.03.009 |