| H01459 | |
| H番号 | H01459 |
| 名称 | 糖尿病性神経障害 |
| 概要 | Diabetic neuropathies (DNs) are nerve-damaging disorders caused by diabetes. Diabetic neuropathy broadly comprises generalized symmetric polyneuropathies (acute sensory, chronic sensorimotor, autonomic) and asymmetric (focal and multifocal) neuropathies (cranial, truncal, focal-limb, proximal-motor, coexisting chronic inflammatory demyelinating), which affect all organs and systems. Of all types, diabetic sensorimotor polyneuropathy (DSPN), also called distal symmetric neuropathy, is the most typical form. Typical symptoms vary from person to person, but may include numbness, tingling, pain, or weakness that typically starts in the feet and progresses up the legs. This pattern of neuropathy shows a progressive distal axonopathy. It has been reported that vascular endothelial growth factor A is associated with DNs development and progression. |
| カテゴリ | 内分泌代謝疾患; 神経系疾患 |
| ネットワーク | - |
| 病因遺伝子 | VEGFA (polymorphism) [HSA:7422] [KO:K05448] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | 塩酸デュロキセチン [DR:D01179] メキシレチン塩酸塩 [DR:D00639] エパルレスタット [DR:D01688] |
| コメント | Pregabalin [DR:D02716] (US and EU approved) |
| リンク | ICD-11: 8C03.0 ICD-10: E14.4 MeSH: D003929 OMIM: 603933 |
| 文献 | PMID:16932298 著者 Vinik A, Ullal J, Parson HK, Casellini CM タイトル Diabetic neuropathies: clinical manifestations and current treatment options. 雑誌 Nat Clin Pract Endocrinol Metab 2:269-81 (2006) DOI:10.1038/ncpendmet0142 PMID:25252500 著者 Gupta A, Gupta Y タイトル Diabetic neuropathy: Part 1. 雑誌 J Pak Med Assoc 64:714-8 (2014) PMID:16461471 著者 Bansal V, Kalita J, Misra UK タイトル Diabetic neuropathy. 雑誌 Postgrad Med J 82:95-100 (2006) DOI:10.1136/pgmj.2005.036137 PMID:26074879 著者 Witzel II, Jelinek HF, Khalaf K, Lee S, Khandoker AH, Alsafar H タイトル Identifying Common Genetic Risk Factors of Diabetic Neuropathies. 雑誌 Front Endocrinol (Lausanne) 6:88 (2015) DOI:10.3389/fendo.2015.00088 |