| H01459 | |
| H number | H01459 |
| Name | Diabetic neuropathy |
| Description | Diabetic neuropathies (DNs) are nerve-damaging disorders caused by diabetes. Diabetic neuropathy broadly comprises generalized symmetric polyneuropathies (acute sensory, chronic sensorimotor, autonomic) and asymmetric (focal and multifocal) neuropathies (cranial, truncal, focal-limb, proximal-motor, coexisting chronic inflammatory demyelinating), which affect all organs and systems. Of all types, diabetic sensorimotor polyneuropathy (DSPN), also called distal symmetric neuropathy, is the most typical form. Typical symptoms vary from person to person, but may include numbness, tingling, pain, or weakness that typically starts in the feet and progresses up the legs. This pattern of neuropathy shows a progressive distal axonopathy. It has been reported that vascular endothelial growth factor A is associated with DNs development and progression. |
| Category | Endocrine and metabolic disease; Nervous system disease |
| Network | - |
| Gene | VEGFA (polymorphism) [HSA:7422] [KO:K05448] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Becaplermin [DR:D03065] Tapentadol hydrochloride [DR:D10199] (DPN) Pregabalin [DR:D02716] Duloxetine hydrochloride [DR:D01179] |
| Comment | Pregabalin [DR:D02716] (US and EU approved) |
| Other DBs | ICD-11: 8C03.0 ICD-10: E14.4 MeSH: D003929 OMIM: 603933 |
| Reference | PMID:16932298 AUTHORS Vinik A, Ullal J, Parson HK, Casellini CM TITLE Diabetic neuropathies: clinical manifestations and current treatment options. JOURNAL Nat Clin Pract Endocrinol Metab 2:269-81 (2006) DOI:10.1038/ncpendmet0142 PMID:25252500 AUTHORS Gupta A, Gupta Y TITLE Diabetic neuropathy: Part 1. JOURNAL J Pak Med Assoc 64:714-8 (2014) PMID:16461471 AUTHORS Bansal V, Kalita J, Misra UK TITLE Diabetic neuropathy. JOURNAL Postgrad Med J 82:95-100 (2006) DOI:10.1136/pgmj.2005.036137 PMID:26074879 AUTHORS Witzel II, Jelinek HF, Khalaf K, Lee S, Khandoker AH, Alsafar H TITLE Identifying Common Genetic Risk Factors of Diabetic Neuropathies. JOURNAL Front Endocrinol (Lausanne) 6:88 (2015) DOI:10.3389/fendo.2015.00088 |