| H01507 | |
| H番号 | H01507 |
| 名称 | 血清反応陰性関節炎 |
| 概要 | Seronegative spondyloarthropathies (SpA) represent a group of chronic articular inflammatory diseases which differ from rheumatoid arthritis for the typical absence of rheumatoid factor in serum, and have in common several epidemiological, pathological, clinical, and radiological features. SpA include ankylosing spondylitis (AS), reactive arthritis (ReA), enteropathic (IBD) associated arthritis, psoriatic arthritis (PsA), as well as undifferentiated, and juvenile SpA. The main clinical manifestations include inflammatory back pain, peripheral arthritis, enthesitis, and extra-skeletal manifestations, such as uveitis. Although the cause of SpA is unknown, it is generally accepted that SpA is a multifactorial disease. Genetics (such as HLA-B27), inflammatory cytokines (such as TNF), and more recently the IL-23/IL-17 cytokine pathway have links to pathogenesis. Biologic agents, particularly TNF blockers, are primary treatment options and have been shown to reduce symptomatic inflammation. |
| カテゴリ | 免疫系疾患 |
| ネットワーク | - |
| 病因遺伝子 | HLA-B [HSA:3106] [KO:K06751] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: FA27.Y MeSH: D025241 OMIM: 106300 |
| 文献 | PMID:24272481 著者 Paparo F, Revelli M, Semprini A, Camellino D, Garlaschi A, Cimmino MA, Rollandi GA, Leone A タイトル Seronegative spondyloarthropathies: what radiologists should know. 雑誌 Radiol Med 119:156-63 (2014) DOI:10.1007/s11547-013-0316-5 PMID:22428451 著者 Wilson G, Folzenlogen DD タイトル Spondyloarthropathies: new directions in etiopathogenesis, diagnosis and treatment. 雑誌 Mo Med 109:69-74 (2012) PMID:19591637 著者 Melis L, Elewaut D タイトル Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease? 雑誌 Arthritis Res Ther 11:233 (2009) DOI:10.1186/ar2722 |