| H01507 | |
| H number | H01507 |
| Name | Seronegative arthritis |
| Description | Seronegative spondyloarthropathies (SpA) represent a group of chronic articular inflammatory diseases which differ from rheumatoid arthritis for the typical absence of rheumatoid factor in serum, and have in common several epidemiological, pathological, clinical, and radiological features. SpA include ankylosing spondylitis (AS), reactive arthritis (ReA), enteropathic (IBD) associated arthritis, psoriatic arthritis (PsA), as well as undifferentiated, and juvenile SpA. The main clinical manifestations include inflammatory back pain, peripheral arthritis, enthesitis, and extra-skeletal manifestations, such as uveitis. Although the cause of SpA is unknown, it is generally accepted that SpA is a multifactorial disease. Genetics (such as HLA-B27), inflammatory cytokines (such as TNF), and more recently the IL-23/IL-17 cytokine pathway have links to pathogenesis. Biologic agents, particularly TNF blockers, are primary treatment options and have been shown to reduce symptomatic inflammation. |
| Category | Immune system disease |
| Network | - |
| Gene | HLA-B [HSA:3106] [KO:K06751] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Triamcinolone acetonide [DR:D00983] Dexamethasone [DR:D00292] Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Hydrocortisone sodium succinate [DR:D00978] Prednisolone [DR:D00472] Prednisolone sodium phosphate [DR:D00981] Prednisone [DR:D00473] Methylprednisolone [DR:D00407] Methylprednisolone sodium succinate [DR:D00751] Methylprednisolone acetate [DR:D00979] Cortisone acetate [DR:D00973] Abatacept [DR:D03203] Apremilast [DR:D08860] Upadacitinib hydrate [DR:D11048] Etanercept [DR:D00742] Infliximab [DR:D02598] Adalimumab [DR:D02597] Certolizumab pegol [DR:D03441] Golimumab [DR:D04358] Ustekinumab [DR:D09214] Secukinumab [DR:D09967] Risankizumab [DR:D11052] |
| Comment | - |
| Other DBs | ICD-11: FA27.Y MeSH: D025241 OMIM: 106300 |
| Reference | PMID:24272481 AUTHORS Paparo F, Revelli M, Semprini A, Camellino D, Garlaschi A, Cimmino MA, Rollandi GA, Leone A TITLE Seronegative spondyloarthropathies: what radiologists should know. JOURNAL Radiol Med 119:156-63 (2014) DOI:10.1007/s11547-013-0316-5 PMID:22428451 AUTHORS Wilson G, Folzenlogen DD TITLE Spondyloarthropathies: new directions in etiopathogenesis, diagnosis and treatment. JOURNAL Mo Med 109:69-74 (2012) PMID:19591637 AUTHORS Melis L, Elewaut D TITLE Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease? JOURNAL Arthritis Res Ther 11:233 (2009) DOI:10.1186/ar2722 |