H01558 | |
H番号 | H01558 |
名称 | 副甲状腺癌 |
概要 | Parathyroid carcinoma (PC) is a highly aggressive endocrine tumor, with an annual incidence of less than 1 per million. Over 90% of patients present with excess parathyroid hormone (PTH), representing <1-5% of all patients with primary hyperparathyroidism. PC is associated with mutations in the HRPT2/CDC73 gene and with decreased parafibromin and calcium-sensing receptor (CASR) expression. Negative parafibromin staining together with a CDC73 gene mutation increases the likelihood of malignancy and also predicts the clinical outcome, namely local invasion and/or metastases and mortality. An increased mortality is predicted by either of these abnormality combined with down regulation of the calcium-sensing receptor (CaSR) expression. |
カテゴリ | がん |
ネットワーク | - |
病因遺伝子 | CDC73/HRPT2 (mutation) [HSA:79577] [KO:K15175] CASR [HSA:846] [KO:K04612] |
病原体 | - |
環境要因 | - |
発癌物質 | - |
治療薬 | シナカルセト塩酸塩 [DR:D03505] |
コメント | - |
リンク | ICD-11: 2E6B ICD-10: D09.3 MeSH: D010282 |
文献 | PMID:26177319 著者 Duan K, Mete O タイトル Parathyroid Carcinoma: Diagnosis and Clinical Implications. 雑誌 Turk Patoloji Derg 31 Suppl 1:80-97 (2015) DOI:10.5146/tjpath.2015.01316 PMID:26312219 著者 McClenaghan F, Qureshi YA タイトル Parathyroid cancer. 雑誌 Gland Surg 4:329-38 (2015) DOI:10.3978/j.issn.2227-684X.2015.05.09 PMID:24035866 著者 Costa-Guda J, Arnold A タイトル Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. 雑誌 Mol Cell Endocrinol 386:46-54 (2014) DOI:10.1016/j.mce.2013.09.005 PMID:20510594 著者 Givi B, Shah JP タイトル Parathyroid carcinoma. 雑誌 Clin Oncol (R Coll Radiol) 22:498-507 (2010) DOI:10.1016/j.clon.2010.04.007 PMID:25002250 著者 Truran PP, Johnson SJ, Bliss RD, Lennard TW, Aspinall SR タイトル Parafibromin, galectin-3, PGP9.5, Ki67, and cyclin D1: using an immunohistochemical panel to aid in the diagnosis of parathyroid cancer. 雑誌 World J Surg 38:2845-54 (2014) DOI:10.1007/s00268-014-2700-2 PMID:26675091 著者 Karaarslan S, Yurum FN, Kumbaraci BS, Pala EE, Sivrikoz ON, Akyildiz M, Bugdayci MH タイトル The Role of Parafibromin, Galectin-3, HBME-1, and Ki-67 in the Differential Diagnosis of Parathyroid Tumors. 雑誌 Oman Med J 30:421-7 (2015) DOI:10.5001/omj.2015.84 PMID:27001435 著者 Cetani F, Pardi E, Marcocci C タイトル Update on parathyroid carcinoma. 雑誌 J Endocrinol Invest 39:595-606 (2016) DOI:10.1007/s40618-016-0447-3 PMID:21240254 著者 Witteveen JE, Hamdy NA, Dekkers OM, Kievit J, van Wezel T, Teh BT, Romijn JA, Morreau H タイトル Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma. 雑誌 Mod Pathol 24:688-97 (2011) DOI:10.1038/modpathol.2010.236 |