| H01558 | |
| H number | H01558 |
| Name | Parathyroid carcinoma |
| Description | Parathyroid carcinoma (PC) is a highly aggressive endocrine tumor, with an annual incidence of less than 1 per million. Over 90% of patients present with excess parathyroid hormone (PTH), representing <1-5% of all patients with primary hyperparathyroidism. PC is associated with mutations in the HRPT2/CDC73 gene and with decreased parafibromin and calcium-sensing receptor (CASR) expression. Negative parafibromin staining together with a CDC73 gene mutation increases the likelihood of malignancy and also predicts the clinical outcome, namely local invasion and/or metastases and mortality. An increased mortality is predicted by either of these abnormality combined with down regulation of the calcium-sensing receptor (CaSR) expression. |
| Category | Cancer |
| Network | - |
| Gene | CDC73/HRPT2 (mutation) [HSA:79577] [KO:K15175] CASR [HSA:846] [KO:K04612] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Cinacalcet hydrochloride [DR:D03505] |
| Comment | - |
| Other DBs | ICD-11: 2E6B ICD-10: D09.3 MeSH: D010282 |
| Reference | PMID:26177319 AUTHORS Duan K, Mete O TITLE Parathyroid Carcinoma: Diagnosis and Clinical Implications. JOURNAL Turk Patoloji Derg 31 Suppl 1:80-97 (2015) DOI:10.5146/tjpath.2015.01316 PMID:26312219 AUTHORS McClenaghan F, Qureshi YA TITLE Parathyroid cancer. JOURNAL Gland Surg 4:329-38 (2015) DOI:10.3978/j.issn.2227-684X.2015.05.09 PMID:24035866 AUTHORS Costa-Guda J, Arnold A TITLE Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. JOURNAL Mol Cell Endocrinol 386:46-54 (2014) DOI:10.1016/j.mce.2013.09.005 PMID:20510594 AUTHORS Givi B, Shah JP TITLE Parathyroid carcinoma. JOURNAL Clin Oncol (R Coll Radiol) 22:498-507 (2010) DOI:10.1016/j.clon.2010.04.007 PMID:25002250 AUTHORS Truran PP, Johnson SJ, Bliss RD, Lennard TW, Aspinall SR TITLE Parafibromin, galectin-3, PGP9.5, Ki67, and cyclin D1: using an immunohistochemical panel to aid in the diagnosis of parathyroid cancer. JOURNAL World J Surg 38:2845-54 (2014) DOI:10.1007/s00268-014-2700-2 PMID:26675091 AUTHORS Karaarslan S, Yurum FN, Kumbaraci BS, Pala EE, Sivrikoz ON, Akyildiz M, Bugdayci MH TITLE The Role of Parafibromin, Galectin-3, HBME-1, and Ki-67 in the Differential Diagnosis of Parathyroid Tumors. JOURNAL Oman Med J 30:421-7 (2015) DOI:10.5001/omj.2015.84 PMID:27001435 AUTHORS Cetani F, Pardi E, Marcocci C TITLE Update on parathyroid carcinoma. JOURNAL J Endocrinol Invest 39:595-606 (2016) DOI:10.1007/s40618-016-0447-3 PMID:21240254 AUTHORS Witteveen JE, Hamdy NA, Dekkers OM, Kievit J, van Wezel T, Teh BT, Romijn JA, Morreau H TITLE Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma. JOURNAL Mod Pathol 24:688-97 (2011) DOI:10.1038/modpathol.2010.236 |