| H01652 | |
| H番号 | H01652 |
| 名称 | 脂漏性皮膚炎 |
| 概要 | Seborrheic dermatitis (SD) is a common inflammatory dermatological disorder. The characteristic symptoms include scaling, erythema, and itching, which occur most often on the scalp, face, chest, back, axilla, and groin. Its incidence peaks during three age periods: in the first three months of life, during puberty, and in adulthood with an apex at 40 to 60 years of age. The cause of SD is unknown and the disease seems to be multifactorial. Malassezia yeasts are considered to play an important role. They cause an inflammatory reaction that seems to be mediated by free fatty acids, released from sebaceous triglycerides by fungal enzymes such as lipases. The lipid layer of Malassezia can also modulate pro-inflammatory cytokine production by keratinocytes. Although it can be associated with human immunodeficiency virus infection and neurologic disease (e.g., cerebrovascular event, Parkinson disease), SD typically occurs in healthy persons. Its prevalence is 1% to 3% in the general population and 34% to 83% in immunocompromised persons. Topical antifungal agents are the first-line therapy for acute and long-term treatment of SD of the face and body. Treatment includes over-the-counter shampoos and topical antifungals, calcineurin inhibitors, and corticosteroids. |
| カテゴリ | 免疫系疾患; 皮膚疾患 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | Malassezia globosa [GN:mgl] Malassezia restricta [GN:mrt] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | デキサメタゾン [DR:D00292] デキサメタゾンリン酸エステルナトリウム [DR:D00975] ベタメタゾンリン酸エステルナトリウム [DR:D00972] トリアムシノロンアセトニド [DR:D00983] ヒドロコルチゾン [DR:D00088] ヒドロコルチゾンコハク酸エステルナトリウム [DR:D00978] コルチゾン酢酸エステル [DR:D00973] トリアムシノロン [DR:D00385] ベタメタゾン [DR:D00244] プレドニゾロン [DR:D00472] プレドニゾロンコハク酸エステルナトリウム [DR:D01239] メチルプレドニゾロン [DR:D00407] メチルプレドニゾロン酢酸エステル [DR:D00979] レゾルシン [DR:D00133] ヒドロコルチゾン酪酸エステル [DR:D01619] ベタメタゾン酪酸エステルプロピオン酸エステル [DR:D02032] ジフロラゾン酢酸エステル [DR:D01327] ジフルプレドナート [DR:D01266] デプロドンプロピオン酸エステル [DR:D01434] ベタメタゾン吉草酸エステル・ゲンタマイシン硫酸塩 [DR:D04773] ウフェナマート [DR:D01823] ケトコナゾール [DR:D00351] イオウ [DR:D00024] カルプロニウム塩化物 [DR:D01175] ピリドキシン塩酸塩 [DR:D02179] ビオチン [DR:D00029] |
| コメント | - |
| リンク | ICD-11: EA81 ICD-10: L21 MeSH: D012628 |
| 文献 | PMID:27148560 著者 Borda LJ, Wikramanayake TC タイトル Seborrheic Dermatitis and Dandruff: A Comprehensive Review. 雑誌 J Clin Investig Dermatol 3:10 (2015) DOI:10.13188/2373-1044.1000019 PMID:26016669 著者 Naldi L, Diphoorn J タイトル Seborrhoeic dermatitis of the scalp. 雑誌 BMJ Clin Evid 2015:1713 (2015) PMID:25822272 著者 Clark GW, Pope SM, Jaboori KA タイトル Diagnosis and treatment of seborrheic dermatitis. 雑誌 Am Fam Physician 91:185-90 (2015) |