| H01703 | |
| H番号 | H01703 |
| 名称 | 中枢性摂食異常症 (摂食障害) |
| 概要 | Eating disorders, which include anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED), are disorders defined by disturbances in eating behavior. Anorexia nervosa (AN) is the oldest recognized eating disorder. The salient features of this eating disorder are a relentless pursuit of thinness, accompanied by a fear of becoming fat despite being markedly underweight. In women, anorexia nervosa is associated with global endocrine dysregulation, including hypothalamic-pituitary axis dysfunction and alterations in adipokine and appetite regulating hormone levels. Bulimia nervosa (BN) is defined by eating behaviors that include episodes of binge eating which are followed by recurrent self-induced vomiting performed in an attempt to avoid weight gain from the caloric overload. Binge eating disorder (BED) is currently characterized by recurrent episodes of binge eating occurring at least twice a week for 6 months or longer. In contrast to bulimia nervosa, there are no inappropriate compensatory behaviors such as vomiting. Eating disorders frequently develop during adolescence or early adulthood, but some studies have reported their onset during childhood or later in adulthood. There is growing evidence supporting a multifactorial etiology that includes genetic, neurochemical, and physiological components for eating disorders above and beyond the more conventional theories based on psychological and sociocultural factors. Brain-derived neurotrophic factor (BDNF) plays a critical role in regulating nerves in the brain. Recent studies have provided evidence that BDNF also plays a role in regulating eating behaviors. In addition, an association between the BDNF gene polymorphism and eating disorders has been demonstrated. Other genetic risk factors for eating disorders have also been reported. |
| カテゴリ | 精神及び行動の障害 |
| ネットワーク | - |
| 病因遺伝子 | BDNF [HSA:627] [KO:K04355] AGRP [HSA:181] [KO:K05231] GHRL [HSA:51738] [KO:K05254] OPRD1 [HSA:4985] [KO:K04213] HTR1D [HSA:3352] [KO:K04153] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: 6B8Y ICD-10: F50 MeSH: D001068 OMIM: 606788 610269 |
| 文献 | PMID:23348361 著者 Heaner MK, Walsh BT タイトル A history of the identification of the characteristic eating disturbances of Bulimia Nervosa, Binge Eating Disorder and Anorexia Nervosa. 雑誌 Appetite 65:185-8 (2013) DOI:10.1016/j.appet.2013.01.005 PMID:12888803 著者 Ribases M, Gratacos M, Armengol L, de Cid R, Badia A, Jimenez L, Solano R, Vallejo J, Fernandez F, Estivill X タイトル Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. 雑誌 Mol Psychiatry 8:745-51 (2003) DOI:10.1038/sj.mp.4001281 PMID:22960103 著者 Atalayer D, Gibson C, Konopacka A, Geliebter A タイトル Ghrelin and eating disorders. 雑誌 Prog Neuropsychopharmacol Biol Psychiatry 40:70-82 (2013) DOI:10.1016/j.pnpbp.2012.08.011 PMID:24831852 著者 Yilmaz Z, Kaplan AS, Tiwari AK, Levitan RD, Piran S, Bergen AW, Kaye WH, Hakonarson H, Wang K, Berrettini WH, Brandt HA, Bulik CM, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson CL, Keel PK, Klump KL, Magistretti P, Mitchell JE, Strober M, Thornton LM, Treasure J, Woodside DB, Knight J, Kennedy JL タイトル The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. 雑誌 J Psychiatr Res 55:77-86 (2014) DOI:10.1016/j.jpsychires.2014.04.005 PMID:15389773 著者 Koronyo-Hamaoui M, Gak E, Stein D, Frisch A, Danziger Y, Leor S, Michaelovsky E, Laufer N, Carel C, Fennig S, Mimouni M, Apter A, Goldman B, Barkai G, Weizman A タイトル CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. 雑誌 Am J Med Genet B Neuropsychiatr Genet 131B:76-80 (2004) DOI:10.1002/ajmg.b.20154 PMID:12740597 著者 Bergen AW, van den Bree MB, Yeager M, Welch R, Ganjei JK, Haque K, Bacanu S, Berrettini WH, Grice DE, Goldman D, Bulik CM, Klump K, Fichter M, Halmi K, Kaplan A, Strober M, Treasure J, Woodside B, Kaye WH タイトル Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. 雑誌 Mol Psychiatry 8:397-406 (2003) DOI:10.1038/sj.mp.4001318 |