| H00028 | |
| H number | H00028 |
| Name | Choriocarcinoma |
| Description | Gestational choriocarcinoma is a highly malignant epithelial tumor that can be associated with any type of gestational event, most often a complete hydatidiform mole (CM). CM occur in about one per 1000 pregnancies, and about 5-20% of CM progress to invasive moles or choriocarcinoma. Several molecular studies have been done to establish the expression of tumor-associated proteins in choriocarcinoma. In the p53 pathway, overexpression of the p53 protein and the p53-associated protein, MDM2, have been detected. Synergistic upregulation of c-MYC, c-ERB-2, c-FMS, and BCL-2 oncoproteins have also been suggested to have an important role in the pathogenesis of choriocarcinoma. Moreover, choriocarcinomas have been shown to express increased concentrations of MMP and decreased concentrations of TIMP to help with tumor invasion and metastasis. |
| Category | Cancer |
| Network | - |
| Gene | p53 (overexpression) [HSA:7157] [KO:K04451] MdM2 (overexpression) [HSA:4193] [KO:K06643] EGFR (overexpression) [HSA:1956] [KO:K04361] c-MYC (overexpression) [HSA:4609] [KO:K04377] ERBB2 (overexpression) [HSA:2064] [KO:K05083] c-FMS (overexpression) [HSA:1436] [KO:K05090] Bcl-2 (overexpression) [HSA:596] [KO:K02161] MMP-1 (overexpression) [HSA:4312] [KO:K01388] MMP-2 (overexpression) [HSA:4313] [KO:K01398] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Methotrexate sodium [DR:D02115] Vinblastine sulfate [DR:D01068] Bleomycin sulfate [DR:D02177] |
| Comment | - |
| Other DBs | ICD-11: 2C75 ICD-10: C58 MeSH: D002822 |
| Reference | PMID:17613426 AUTHORS Shih IeM. TITLE Gestational trophoblastic neoplasia--pathogenesis and potential therapeutic targets. JOURNAL Lancet Oncol 8:642-50 (2007) DOI:10.1016/S1470-2045(07)70204-8 PMID:11869089 AUTHORS Li HW, Tsao SW, Cheung AN TITLE Current understandings of the molecular genetics of gestational trophoblastic diseases. JOURNAL Placenta 23:20-31 (2002) DOI:10.1053/plac.2001.0744 PMID:17304028 AUTHORS Garner EI, Goldstein DP, Feltmate CM, Berkowitz RS. TITLE Gestational trophoblastic disease. JOURNAL Clin Obstet Gynecol 50:112-22 (2007) DOI:10.1097/GRF.0b013e31802f17fc |