| H00319 | |
| H number | H00319 |
| Name | Pertussis; Whooping cough |
| Description | Pertussis, or whooping cough, caused by the gram-negative bacillus Bordetella pertussis, is a highly contagious, acute respiratory disease of humans. Despite high vaccination rates, this illness has re-emerged worldwide, causing approximately 300 000 deaths each year. Waning immunity after childhood immunization has resulted in a growing pool of susceptible adolescents and adults who are capable of transmitting pertussis to vulnerable unvaccinated or incompletely vaccinated infants. The hallmark symptoms of pertussis are paroxysmal coughing with whooping and post-tussive vomiting. Persistent coughing may last for weeks to months with a gradual decrease in frequency and severity. However, it should be noted that B. pertussis infections, particularly in hosts with partial immunity to the bacterium, may also follow a much milder or subclinical course. Complications that are frequently associated with classical pertussis include pneumonia, otitis media, seizures, encephalopathy, and (brain) hemorrhages. |
| Category | Bacterial infectious disease DIS_PATHWAY hsa05133 Pertussis |
| Network | - |
| Gene | - |
| Pathogen | Bordetella pertussis [GN:bpe bpc bpet] Bordetella parapertussis [GN:bpa] |
| Env factor | - |
| Carcinogen | - |
| Drug | Erythromycin [DR:D00140] Erythromycin ethylsuccinate [DR:D01361] Erythromycin stearate [DR:D02184] |
| Comment | - |
| Other DBs | ICD-11: 1C12 ICD-10: A37 MeSH: D014917 MedlinePlus: 001561 |
| Reference | PMID:21204863 AUTHORS de Gouw D, Diavatopoulos DA, Bootsma HJ, Hermans PW, Mooi FR TITLE Pertussis: a matter of immune modulation. JOURNAL FEMS Microbiol Rev 35:441-74 (2011) DOI:10.1111/j.1574-6976.2010.00257.x PMID:19879977 AUTHORS Mooi FR TITLE Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen. JOURNAL Infect Genet Evol 10:36-49 (2010) DOI:10.1016/j.meegid.2009.10.007 PMID:10943406 AUTHORS Locht C TITLE Molecular aspects of Bordetella pertussis pathogenesis. JOURNAL Int Microbiol 2:137-44 (1999) PMID:20109046 AUTHORS Heininger U TITLE Update on pertussis in children. JOURNAL Expert Rev Anti Infect Ther 8:163-73 (2010) DOI:10.1586/eri.09.124 PMID:16522501 AUTHORS Munoz FM TITLE Pertussis in infants, children, and adolescents: diagnosis, treatment, and prevention. JOURNAL Semin Pediatr Infect Dis 17:14-9 (2006) DOI:10.1053/j.spid.2005.11.005 |