|Name||Helicobacter pylori infection|
|Description||Helicobacter pylori (HP) is a gram-negative pathogenic bacterium that specifically colonizes in the gastric epithelium and causes chronic gastritis, peptic ulcer disease, and/or gastric malignancies. Persistent infection can cause inflammation and gastritis that may lead to carcinogenesis. Transmission is still not entirely clarified, but human-to-human spread through oral-oral or fecal-oral route is thought to be the most plausible. The prevalence of HP infection varies between different geographical regions; generally, the prevalence is about 30% in developed and up to 80% in developing countries. Although HP may sometimes be eradicated by antibiotics given for other infections, infection usually persists life-long unless specific combination antibiotic therapy is taken.|
|Pathogen|| Helicobacter pylori [GN:hpy hpj hpa hps hpg hpp hpb hpl hpi hpq hpw hef hpf heq hex hpv hey hpyb hpyc hpyd hpye hpyf hpyg hpyh hpyj heb hez]
vacuolating cytotoxin [KO:K11028]
|Drug||proton pump inhibitors [DG:DG00020 DG00021 DG00022 DG00023] [ATC:A02BC]
Bismuth subsalicylate [DG:DG00027]
|Other DBs||ICD-10: A49.8
Helicobacter pylori infection and its relationship to metabolic syndrome: is it a myth or fact?
Saudi J Gastroenterol 17:165-9 (2011)
Goh KL, Chan WK, Shiota S, Yamaoka Y
Epidemiology of Helicobacter pylori infection and public health implications.
Helicobacter 16 Suppl 1:1-9 (2011)
The current status of Helicobacter pylori vaccines: a review.
Helicobacter 12:89-102 (2007)
Moss SF, Sood S
Curr Opin Infect Dis 16:445-51 (2003)