| H00354 | |
| H number | H00354 |
| Name | Syphilis |
| Description | Syphilis is one of the oldest recognized venereal infections caused by the spirochete Treponema pallidum subsp. pallidum. It is characterized by genital ulceration, skin rash, and development of serious systemic disease. Syphilis may also alter the course of HIV disease. Effective therapy is available but the incidence is increasing in many parts of the world. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Treponema pallidum [GN:tpa tpw tpp tpu tph tpo tpas] |
| Env factor | - |
| Carcinogen | - |
| Drug | Tetracycline hydrochloride [DR:D02122] Doxycycline [DR:D00307] Doxycycline hyclate [DR:D02129] Doxycycline calcium [DR:D03903] Minocycline hydrochloride [DR:D00850] Demeclocycline hydrochloride [DR:D00290] Erythromycin [DR:D00140] Erythromycin ethylsuccinate [DR:D01361] Erythromycin stearate [DR:D02184] Penicillin G potassium [DR:D01053] Penicillin G benzathine [DR:D02157] Penicillin G procaine [DR:D02461] Penicillin G sodium [DR:D05408] |
| Comment | - |
| Other DBs | ICD-11: 1A60 1A61 1A62 ICD-10: A50 A51 A52 A53 MeSH: D013587 MedlinePlus: 001327 |
| Reference | PMID:11825779 AUTHORS Antal GM, Lukehart SA, Meheus AZ TITLE The endemic treponematoses. JOURNAL Microbes Infect 4:83-94 (2002) DOI:10.1016/S1286-4579(01)01513-1 PMID:22133883 AUTHORS Ho EL, Lukehart SA TITLE Syphilis: using modern approaches to understand an old disease. JOURNAL J Clin Invest 121:4584-92 (2011) DOI:10.1172/JCI57173 PMID:18510892 AUTHORS Daskalakis D TITLE Syphilis: continuing public health and diagnostic challenges. JOURNAL Curr HIV/AIDS Rep 5:72-7 (2008) DOI:10.1007/s11904-008-0012-6 |