| H00412 | |
| H number | H00412 |
| Name | Hepatitis B; Hepatitis B virus (HBV) infection |
| Description | Hepatitis B is an infectious disease caused by hepatitis B virus (HBV) belonging to the Hepadnaviridae family of dsDNA-RT viruses. Both acute and chronic hepatitis B can be caused by blood-borne HBV infections. The risk of developing chronic hepatitis B is directly related to the age of first infection, much higher for infants. Chronic hepatitis B may eventually lead to cirrhosis and hepatocellular carcinoma. |
| Category | Viral infectious disease DIS_PATHWAY hsa05161 Hepatitis B |
| Network | nt06162 Hepatitis B virus (HBV) |
| Gene | IFNAR2 (susceptibility) [HSA:3455] [KO:K05131] IFNGR1 (susceptibility) [HSA:3459] [KO:K05132] IL10RB (susceptibility) [HSA:3588] [KO:K05135] |
| Pathogen | Hepatitis B virus (HBV) [GN:T40004] |
| Env factor | - |
| Carcinogen | - |
| Drug | Lamivudine [DR:D00353] Tenofovir disoproxil fumarate [DR:D01982] Adefovir dipivoxil [DR:D01655] Entecavir [DR:D04008] Telbivudine [DR:D06675] Tenofovir alafenamide fumarate [DR:D10605] Hepatitis B immune globulin [DR:D04431] Interferon alfa-2b [DR:D02745] Peginterferon alfa-2a [DR:D02747] |
| Comment | - |
| Other DBs | ICD-11: 1E50.1 1E51.0 ICD-10: B16 MeSH: D006509 MedlinePlus: 000279 OMIM: 610424 |
| Reference | PMID:22252919 AUTHORS Nebbia G, Peppa D, Maini MK TITLE Hepatitis B infection: current concepts and future challenges. JOURNAL QJM 105:109-13 (2012) DOI:10.1093/qjmed/hcr270 PMID:12000599 AUTHORS Pramoolsinsup C TITLE Management of viral hepatitis B. JOURNAL J Gastroenterol Hepatol 17 Suppl:S125-45 (2002) DOI:10.1046/j.1440-1746.17.s1.3.x PMID:22171125 AUTHORS Tan YJ TITLE Hepatitis B virus infection and the risk of hepatocellular carcinoma. JOURNAL World J Gastroenterol 17:4853-7 (2011) DOI:10.3748/wjg.v17.i44.4853 PMID:16757563 (IFNAR2, IL10RB) AUTHORS Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, Chiaramonte M, Bell JI, Graves M, Whittle HC, Thomas HC, Thursz MR, Hill AV TITLE Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. JOURNAL Proc Natl Acad Sci U S A 103:9148-53 (2006) DOI:10.1073/pnas.0602800103 PMID:19488747 (IFNGR1) AUTHORS Zhou J, Chen DQ, Poon VK, Zeng Y, Ng F, Lu L, Huang JD, Yuen KY, Zheng BJ TITLE A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. JOURNAL Immunogenetics 61:423-30 (2009) DOI:10.1007/s00251-009-0377-8 |