H00630 | |
H number | H00630 |
Name | Rheumatoid arthritis |
Description | Rheumatoid arthritis (RA) is a common autoimmune disease that primarily manifests as chronic inflammatory arthropathy. Persistent synovitis leads to cartilage destruction, bone erosions and periarticular decalcification, subsequently resulting in impaired joint function. It is more common between the ages of 35 and 50 years, affecting three times more women than men. Susceptibility to RA is genetically determined with multiple genes contributing. Inheritance of HLA DRB1 alleles encoding a distinctive five-amino-acid sequence known as the "shared epitope" (SE) is the best characterized genetic risk factor. The mechanism by which the SE alleles contribute to the development of RA is not very clear. It has been postulated that the presence of these conserved sequences in the antigen-binding groove alters the way antigenic peptides are bound to and presented to T-cell lymphocytes. This, in turn, may trigger abnormal immune responses and lead to RA. |
Category | Immune system disease DIS_PATHWAY hsa05323 Rheumatoid arthritis |
Network | - |
Gene | HLA-DRB1 [HSA:3123] [KO:K06752] PTPN22 [HSA:26191] [KO:K18024] CIITA [HSA:4261] [KO:K08060] CD244 [HSA:51744] [KO:K06582] SLC22A4 [HSA:6583] [KO:K08202] IRF5 [HSA:3663] [KO:K09446] NFKBIL1 [HSA:4795] [KO:K09256] IL10 [HSA:3586] [KO:K05443] (JIA) IL6 [HSA:3569] [KO:K05405] (JIA) MIF [HSA:4282] [KO:K07253] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Triamcinolone acetonide [DR:D00983] Dexamethasone [DR:D00292] Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Hydrocortisone sodium succinate [DR:D00978] Prednisolone [DR:D00472] Prednisolone sodium phosphate [DR:D00981] Prednisone [DR:D00473] Sulfasalazine [DR:D00448] Indomethacin [DR:D00141] Methylprednisolone [DR:D00407] Methylprednisolone sodium succinate [DR:D00751] Methylprednisolone acetate [DR:D00979] Naproxen [DR:D00118] Naproxen sodium [DR:D00970] Corticotropin [DR:D00146] Cortisone acetate [DR:D00973] Methotrexate [DR:D00142] Methotrexate sodium [DR:D02115] Rituximab [DR:D02994] Celecoxib [DR:D00567] Leflunomide [DR:D00749] Abatacept [DR:D03203] Tofacitinib citrate [DR:D09783] Baricitinib [DR:D10308] Upadacitinib hydrate [DR:D11048] Etanercept [DR:D00742] Infliximab [DR:D02598] Adalimumab [DR:D02597] Certolizumab pegol [DR:D03441] Golimumab [DR:D04358] Anakinra [DR:D02934] Tocilizumab [DR:D02596] Sarilumab [DR:D10161] Cyclosporine [DR:D00184] Azathioprine [DR:D00238] Diclofenac sodium and misoprostol [DR:D11091] Piroxicam [DR:D00127] Fenoprofen calcium [DR:D00968] Flurbiprofen [DR:D00330] Oxaprozin [DR:D00463] Ibuprofen and famotidine [DR:D11575] Naproxen and esomeprazole magnesium [DR:D11576] Meclofenamate sodium [DR:D00169] Auranofin [DR:D00237] Salsalate [DR:D00428] Hydroxychloroquine sulfate [DR:D02114] Lobenzarit sodium [DR:D01808] |
Comment | - |
Other DBs | ICD-11: FA20 ICD-10: M05 MeSH: D001172 OMIM: 180300 604302 |
Reference | PMID:27338350 AUTHORS Chung IM, Ketharnathan S, Thiruvengadam M, Rajakumar G TITLE Rheumatoid Arthritis: The Stride from Research to Clinical Practice. JOURNAL Int J Mol Sci 17:E900 (2016) DOI:10.3390/ijms17060900 PMID:22704962 AUTHORS Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N, Falgarone G TITLE Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. JOURNAL J Autoimmun 39:222-8 (2012) DOI:10.1016/j.jaut.2012.05.021 PMID:14608356 AUTHORS Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K TITLE An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. JOURNAL Nat Genet 35:341-8 (2003) DOI:10.1038/ng1267 PMID:20980283 AUTHORS Dawidowicz K, Allanore Y, Guedj M, Pierlot C, Bombardieri S, Balsa A, Westhovens R, Barrera P, Alves H, Teixeira VH, Petit-Teixeira E, van de Putte L, van Riel P, Prum B, Bardin T, Meyer O, Cornelis F, Dieude P TITLE The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype. JOURNAL Ann Rheum Dis 70:117-21 (2011) DOI:10.1136/ard.2010.129171 PMID:15208781 AUTHORS Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, Spoerke JM, Conn MT, Chang M, Chang SY, Saiki RK, Catanese JJ, Leong DU, Garcia VE, McAllister LB, Jeffery DA, Lee AT, Batliwalla F, Remmers E, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, Gregersen PK TITLE A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. JOURNAL Am J Hum Genet 75:330-7 (2004) DOI:10.1086/422827 PMID:17665434 AUTHORS Marinou I, Healy J, Mewar D, Moore DJ, Dickson MC, Binks MH, Montgomery DS, Walters K, Wilson AG TITLE Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status. JOURNAL Arthritis Rheum 56:2549-56 (2007) DOI:10.1002/art.22814 PMID:15821736 AUTHORS Swanberg M, Lidman O, Padyukov L, Eriksson P, Akesson E, Jagodic M, Lobell A, Khademi M, Borjesson O, Lindgren CM, Lundman P, Brookes AJ, Kere J, Luthman H, Alfredsson L, Hillert J, Klareskog L, Hamsten A, Piehl F, Olsson T TITLE MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. JOURNAL Nat Genet 37:486-94 (2005) DOI:10.1038/ng1544 PMID:12509789 AUTHORS Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H TITLE Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. JOURNAL Am J Hum Genet 72:303-12 (2003) DOI:10.1086/346067 PMID:18794858 AUTHORS Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K, Kamatani Y, Mori M, Shimane K, Hirabayashi Y, Takahashi A, Tsunoda T, Miyatake A, Kubo M, Kamatani N, Nakamura Y, Yamamoto K TITLE Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. JOURNAL Nat Genet 40:1224-9 (2008) DOI:10.1038/ng.205 |