| H00681 | |
| H number | H00681 |
| Name | Acne inversa; Hidradenitis suppurativa |
| Description | Acne inversa (AI), also known as hidradenitis suppurativa, is a chronic inflammatory disorder of hair follicles involving the apocrine gland-bearing areas of the body. Its characteristic features include recurrent formation of painful skin abscesses, fistulating sinuses, and disfiguring scars. |
| Category | Skin disease |
| Network | nt06511(H00681) NOTCH signaling |
| Gene | (ACNINV1) NCSTN [HSA:23385] [KO:K06171] (ACNINV2) PSENEN [HSA:55851] [KO:K06170] (ACNINV3) PSEN1 [HSA:5663] [KO:K04505] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Adalimumab [DR:D02597] |
| Comment | - |
| Other DBs | ICD-11: ED92.0 ICD-10: L73.2 MeSH: D017497 OMIM: 613737 142690 613736 |
| Reference | PMID:21192260 AUTHORS Yazdanyar S, Jemec GB TITLE Hidradenitis suppurativa: a review of cause and treatment. JOURNAL Curr Opin Infect Dis 24:118-23 (2011) DOI:10.1097/QCO.0b013e3283428d07 PMID:21495993 (ACNINV1/2/3) AUTHORS Li CR, Jiang MJ, Shen DB, Xu HX, Wang HS, Yao X, Zhang Y, Zhou WQ, Wang B TITLE Two novel mutations of the nicastrin gene in Chinese patients with acne inversa. JOURNAL Br J Dermatol 165:415-8 (2011) DOI:10.1111/j.1365-2133.2011.10372.x PMID:20929727 (ACNINV1/2/3) AUTHORS Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X TITLE Gamma-secretase gene mutations in familial acne inversa. JOURNAL Science 330:1065 (2010) DOI:10.1126/science.1196284 |