| H00731 | |
| H number | H00731 |
| Name | Atrial fibrillation |
| Description | Atrial fibrillation (AF, ATFB) is the most common cardiac arrhythmia and is regarded generally as a sporadic, acquired disorder. Nevertheless, recent growing evidence points to an important heritable basis for AF. By linkage analysis, several loci have been mapped for monogenetic AF. Some of these loci encode for subunits of potassium channels. |
| Category | Cardiovascular disease |
| Network | - |
| Gene | (ATFB3) KCNQ1 [HSA:3784] [KO:K04926] (ATFB4) KCNE2 [HSA:9992] [KO:K04896] (ATFB6) NPPA [HSA:4878] [KO:K12334] (ATFB7) KCNA5 [HSA:3741] [KO:K04878] (ATFB9) KCNJ2 [HSA:3759] [KO:K04996] (ATFB10) SCN5A [HSA:6331] [KO:K04838] (ATFB11) GJA5 [HSA:2702] [KO:K07614] (ATFB12) ABCC9 [HSA:10060] [KO:K05033] (ATFB13) SCN1B [HSA:6324] [KO:K04845] (ATFB14) SCN2B [HSA:6327] [KO:K04846] (ATFB15) NUP155 [HSA:9631] [KO:K14312] (ATFB16) SCN3B [HSA:55800] [KO:K04847] (ATFB17) SCN4B [HSA:6330] [KO:K04848] (ATFB18) MYL4 [HSA:4635] [KO:K12750] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Quinidine sulfate [DR:D02272] Flecainide acetate [DR:D00638] Propranolol hydrochloride [DR:D00483] Verapamil hydrochloride [DR:D00619] |
| Comment | - |
| Other DBs | ICD-11: BC81.3 ICD-10: I48 OMIM: 608583 607554 611493 612201 612240 613980 614022 614049 614050 615377 615378 615770 613120 611819 617280 |
| Reference | PMID:18634977 AUTHORS Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT TITLE Molecular genetics of atrial fibrillation. JOURNAL J Am Coll Cardiol 52:241-50 (2008) DOI:10.1016/j.jacc.2008.02.072 PMID:17768091 AUTHORS Otway R, Vandenberg JI, Fatkin D TITLE Atrial fibrillation--a new cardiac channelopathy. JOURNAL Heart Lung Circ 16:356-60 (2007) DOI:10.1016/j.hlc.2007.07.003 PMID:12522251 (ATFB3) AUTHORS Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W TITLE KCNQ1 gain-of-function mutation in familial atrial fibrillation. JOURNAL Science 299:251-4 (2003) DOI:10.1126/science.1077771 PMID:15368194 (ATFB4) AUTHORS Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, Liang B, Lin J, Liu Y, Liu B, Zhou Q, Zhang D, Wang R, Ma N, Su X, Niu K, Pei Y, Xu W, Chen Z, Wan H, Cui J, Barhanin J, Chen Y TITLE Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. JOURNAL Am J Hum Genet 75:899-905 (2004) DOI:10.1086/425342 PMID:18614783 (ATFB6) AUTHORS Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett JC Jr, Olson TM TITLE Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. JOURNAL N Engl J Med 359:158-65 (2008) DOI:10.1056/NEJMoa0706300 PMID:16772329 (ATFB7) AUTHORS Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A TITLE Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. JOURNAL Hum Mol Genet 15:2185-91 (2006) DOI:10.1093/hmg/ddl143 PMID:15922306 (ATFB9) AUTHORS Xia M, Jin Q, Bendahhou S, He Y, Larroque MM, Chen Y, Zhou Q, Yang Y, Liu Y, Liu B, Zhu Q, Zhou Y, Lin J, Liang B, Li L, Dong X, Pan Z, Wang R, Wan H, Qiu W, Xu W, Eurlings P, Barhanin J, Chen Y TITLE A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. JOURNAL Biochem Biophys Res Commun 332:1012-9 (2005) DOI:10.1016/j.bbrc.2005.05.054 PMID:16684018 (ATFB10) AUTHORS Laitinen-Forsblom PJ, Makynen P, Makynen H, Yli-Mayry S, Virtanen V, Kontula K, Aalto-Setala K TITLE SCN5A mutation associated with cardiac conduction defect and atrial arrhythmias. JOURNAL J Cardiovasc Electrophysiol 17:480-5 (2006) DOI:10.1111/j.1540-8167.2006.00411.x PMID:16790700 (ATFB11) AUTHORS Gollob MH, Jones DL, Krahn AD, Danis L, Gong XQ, Shao Q, Liu X, Veinot JP, Tang AS, Stewart AF, Tesson F, Klein GJ, Yee R, Skanes AC, Guiraudon GM, Ebihara L, Bai D TITLE Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. JOURNAL N Engl J Med 354:2677-88 (2006) DOI:10.1056/NEJMoa052800 PMID:17245405 (ATFB12) AUTHORS Olson TM, Alekseev AE, Moreau C, Liu XK, Zingman LV, Miki T, Seino S, Asirvatham SJ, Jahangir A, Terzic A TITLE KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. JOURNAL Nat Clin Pract Cardiovasc Med 4:110-6 (2007) DOI:10.1038/ncpcardio0792 PMID:19808477 (ATFB13 ATFB14) AUTHORS Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM TITLE Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. JOURNAL Circ Arrhythm Electrophysiol 2:268-75 (2009) DOI:10.1161/CIRCEP.108.779181 PMID:19070573 (ATFB15) AUTHORS Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, Wang QK TITLE Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death. JOURNAL Cell 135:1017-27 (2008) DOI:10.1016/j.cell.2008.10.022 PMID:21051419 (ATFB16) AUTHORS Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH TITLE Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation. JOURNAL Cardiovasc Res 89:786-93 (2011) DOI:10.1093/cvr/cvq348 PMID:23604097 (ATFB17) AUTHORS Li RG, Wang Q, Xu YJ, Zhang M, Qu XK, Liu X, Fang WY, Yang YQ TITLE Mutations of the SCN4B-encoded sodium channel beta4 subunit in familial atrial fibrillation. JOURNAL Int J Mol Med 32:144-50 (2013) DOI:10.3892/ijmm.2013.1355 PMID:27066836 (ATFB18) AUTHORS Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH TITLE A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. JOURNAL Nat Commun 7:11303 (2016) DOI:10.1038/ncomms11303 |