| H01597 | |
| H number | H01597 |
| Name | Restless legs syndrome; Willis Ekbom disease |
| Description | The restless legs syndrome (RLS), also known as Willis Ekbom disease is a neurologic disorder characterized by unpleasant sensations in the legs accompanied by an urge to move them (akathisia). These symptoms occur predominantly at rest and worsen at night, resulting in nocturnal insomnia and chronic sleep deprivation. The prevalence of RLS increases with age and appears to be higher among women than among men. RLS has a high familial aggregation. To date, several loci and genetic risk factors have been identified, but no causative gene mutation has been found. Standard medications for RLS are dopamine agonists and CACN alpha-2 delta blocker. A high prevalence of iron deficiency has been found among patients with RLS. It has been reported that treatment with oral iron supplements resulted in improvements in the severity of the symptoms in patients with a low serum ferritin level. |
| Category | Nervous system disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Gabapentin enacarbil [DR:D09539] Ropinirole hydrochloride [DR:D00784] Pramipexole dihydrochloride [DR:D00559] Rotigotine [DR:D05768] |
| Comment | - |
| Other DBs | ICD-11: 7A80 ICD-10: G25.8 MeSH: D012148 OMIM: 102300 |
| Reference | PMID:12761367 AUTHORS Earley CJ TITLE Clinical practice. Restless legs syndrome. JOURNAL N Engl J Med 348:2103-9 (2003) DOI:10.1056/NEJMcp021288 PMID:23192925 AUTHORS Weissbach A, Siegesmund K, Bruggemann N, Schmidt A, Kasten M, Pichler I, Muhle H, Lohmann E, Lohnau T, Schwinger E, Hagenah J, Stephani U, Pramstaller PP, Klein C, Lohmann K TITLE Exome sequencing in a family with restless legs syndrome. JOURNAL Mov Disord 27:1686-9 (2012) DOI:10.1002/mds.25191 PMID:27224246 AUTHORS Ferini-Strambi L, Marelli S, Galbiati A TITLE Clinical pharmacology and efficacy of rotigotine (Neupro(R) patch) in the treatment of restless leg syndrome. JOURNAL Expert Opin Drug Metab Toxicol 1-9 (2016) DOI:10.1080/17425255.2016.1194393 |