H01634 | |
H number | H01634 |
Name | Peptic ulcer |
Description | Peptic ulcer is a common disorder of gastrointestinal system characterized by mucosal damage secondary to pepsin and gastric acid secretion. It usually occurs in the stomach and proximal duodenum. Typical symptoms include episodic burning epigastric pain, loss of appetite, and weight loss. Pain usually occurs two to five hours after meals or on an empty stomach. The most common causes of peptic ulcer are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Smoking increases the risk of ulcer recurrence and slows healing. Most patients are treated successfully with eradication of H. pylori and/or avoidance of NSAIDs, along with the appropriate use of antisecretory therapy. About 25 percent of patients with peptic ulcer have a serious complication such as hemorrhage, perforation, or gastric outlet obstruction. Administration of proton pump inhibitors (PPIs) and endoscopic therapy control most bleeds. |
Category | Digestive system disease |
Network | - |
Gene | - |
Pathogen | Helicobacter pylori [GN:hpy hpj hpa hps hpg hpp hpb hpl hpi hpq hpw hef hpf heq hex hpv hey hpyb hpyc hpyd hpye hpyf hpyg hpyh hpyj heb hez] |
Env factor | - |
Carcinogen | - |
Drug | Cimetidine [DR:D00295] Cimetidine hydrochloride [DR:D03503] Ranitidine hydrochloride [DR:D00673] Famotidine [DR:D00318] Nizatidine [DR:D00440] Misoprostol [DR:D00419] Omeprazole [DR:D00455] Omeprazole magnesium [DR:D05259] Lansoprazole [DR:D00355] Rabeprazole sodium [DR:D00724] Esomeprazole magnesium [DR:D01984] Esomeprazole sodium [DR:D04056] Esomeprazole strontium [DR:D10120] Esomeprazole magnesium dihydrate [DR:D11114] Sucralfate [DR:D00446] Glycopyrrolate [DR:D00540] Propantheline bromide [DR:D00481] Hyoscyamine sulfate [DR:D00719] Chlordiazepoxide hydrochloride and clidinium bromide [DR:D10247] Ibuprofen and famotidine [DR:D11575] Naproxen and esomeprazole magnesium [DR:D11576] Methscopolamine bromide [DR:D00715] Omeprazole and sodium bicarbonate [DR:D11706] |
Comment | See also H00320 Helicobacter pylori infection. |
Other DBs | ICD-11: DA60 DA61 DA62 DA63 ICD-10: K25 K26 K27 K28 MeSH: D010437 |
Reference | PMID:17956071 AUTHORS Ramakrishnan K, Salinas RC TITLE Peptic ulcer disease. JOURNAL Am Fam Physician 76:1005-12 (2007) PMID:25955624 AUTHORS Fashner J, Gitu AC TITLE Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection. JOURNAL Am Fam Physician 91:236-42 (2015) PMID:2892567 AUTHORS Weir DG TITLE Peptic ulceration. JOURNAL Br Med J (Clin Res Ed) 296:195-200 (1988) |