| H01637 | |
| H number | H01637 |
| Name | Hypertriglyceridemia |
| Description | Hypertriglyceridemia (HTG) is a condition with fasting triglyceride (TG) levels in blood continuing to rise. HTG generally refers to an increase of plasma triglyceride (TG) concentrations above the 95th percentile for age and gender of a reference population. HTG has generally been classified as primary when a definite familial or inherited basis is suspected, whereas secondary HTG refers to cases where there coexist one or more identifiable secondary conditions such as metabolic syndrome, type 2 diabetes (T2D), alcohol consumption, various medications, renal insufficiency, pregnancy, etc. Genetic conditions with HTG include familial HTG (FHTG), familial combined hyperlipidemia (FCHL) [DS:H00153], and familial dysbetalipoproteinemia (Type III hyperlipidemia) [DS:H00156]. Three drug classes are clinically available for treatment of HTG, fibrates, niacin and n-3 fatty acids. Each of these classes has limitations. There is inconsistency in the evidence base for cardiovascular risk reduction using fibrates, the use of niacin is associated with significant side effects, and there are limited data on the use of n-3 fatty acids to reduce cardiovascular risk. |
| Category | Endocrine and metabolic disease |
| Network | - |
| Gene | (HYTG1) APOA5 [HSA:116519] [KO:K09025] (HYTG2) CREB3L3 [HSA:84699] [KO:K09048] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Niacin [DR:D00049] Rosuvastatin calcium [DR:D01915] Fenofibrate [DR:D00565] Choline fenofibrate [DR:D08890] Omega-3-acid ethyl esters [DR:D05255] Icosapent ethyl [DR:D01892] Fenofibric acid [DR:D11579] |
| Comment | - |
| Other DBs | ICD-11: 5C80.1 ICD-10: E78.1 E78.2 E78.4 MeSH: D015228 OMIM: 145750 619324 |
| Reference | PMID:25554923 AUTHORS Lewis GF, Xiao C, Hegele RA TITLE Hypertriglyceridemia in the genomic era: a new paradigm. JOURNAL Endocr Rev 36:131-47 (2015) DOI:10.1210/er.2014-1062 PMID:12915450 AUTHORS Kao JT, Wen HC, Chien KL, Hsu HC, Lin SW TITLE A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. JOURNAL Hum Mol Genet 12:2533-9 (2003) DOI:10.1093/hmg/ddg255 PMID:21666694 AUTHORS Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH TITLE The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. JOURNAL Nat Med 17:812-5 (2011) DOI:10.1038/nm.2347 |