| H01664 | |
| H number | H01664 |
| Name | Panic disorder |
| Description | Panic disorder (PD) is a common type of anxiety disorder, characterized by unexpected and repeated panic attacks or fear of future panic attacks. It has a rapid onset and includes symptoms such as palpitations, chest pain, sweating and shaking. Some physical illnesses (e.g. asthma) commonly occur with panic disorder, and certain lifestyle factors (e.g. smoking) increase the risk for the disorder, but causal pathways are still unclear. In recent years, an association was found between panic symptoms and increased activity in the right frontal region of the brain. Genetic susceptibility factors also exist, but their exact nature and pathophysiological mechanisms remain unknown. Cognitive behavioural therapy (CBT) and several medications, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) and benzodiazepines are effective for PD. Among these, SSRIs and SNRIs are considered to be first-line treatment agents because of their efficacy and favorable side effect profile. |
| Category | Mental disorder |
| Gene | - |
| Pathogen | - |
| Env factor | Nicotine [CPD:C00745] Caffeine [CPD:C07481] |
| Carcinogen | - |
| Marker | - |
| Drug | Paroxetine [DR:D02260] Sertraline [DR:D00825] Venlafaxine [DR:D00821] Imipramine [DR:D00815] |
| Comment | - |
| Other DBs | ICD-10: F41.0 MeSH: D016584 OMIM: 167870 |
| Reference | PMID:16980119 Roy-Byrne PP, Craske MG, Stein MB Panic disorder. Lancet 368:1023-32 (2006) DOI:10.1016/S0140-6736(06)69418-X PMID:25230088 Li H, Wang J, Li C, Xiao Z Repetitive transcranial magnetic stimulation (rTMS) for panic disorder in adults. Cochrane Database Syst Rev CD009083 (2014) DOI:10.1002/14651858.CD009083.pub2 PMID:27089322 (drug) Giampaolo P, Alessandra A, Raffaele B, Elisa M, Giuseppina D, Paolo C, Maria N, Daniela C Is There Room for Second-Generation Antipsychotics in the Pharmacotherapy of Panic Disorder? A Systematic Review Based on PRISMA Guidelines. Int J Mol Sci 17:551 (2016) DOI:10.3390/ijms17040551 |