H01730 | |
H number | H01730 |
Name | Myocardial infarction |
Description | Myocardial infarction (MI) or acute myocardial infarction (AMI) is a term for an event of heart attack. It is due to formation of plaques in the interior walls of the arteries resulting in reduced blood flow to the heart and injuring heart muscles because of lack of oxygen supply. The symptoms of MI include chest pain, which travels from left arm to neck, shortness of breath, nausea, epigastric discomfort, syncope, diaphoresis, and other factors. The diagnosis of MI is dependent on the sensitivity and specificity of the clinical criteria, electrocardiographic (ECG) findings, imaging studies and biomarkers used to detect death of cardiomyocytes. The treatment of MI includes, aspirin tablets, and to dissolve arterial blockage injection of thrombolytic or clot dissolving drugs such as tissue plasminogen activator, streptokinase or urokinase in blood within 3 h of the onset of a heart attack. Nitroglycerin and antihypertensive drugs such as beta-blockers and ACE inhibitors may also be used to lower blood pressure and to improve the oxygen demand of heart. |
Category | Cardiovascular disease |
Network | - |
Gene | ESR1 [HSA:2099] [KO:K08550] F13A1 [HSA:2162] [KO:K03917] F7 [HSA:2155] [KO:K01320] GCLC [HSA:2729] [KO:K11204] GCLM [HSA:2730] [KO:K11205] ITGB3 [HSA:3690] [KO:K06493] LRP8 [HSA:7804] [KO:K20052] LTA [HSA:4049] [KO:K05468] OLR1 [HSA:4973] [KO:K08763] PSMA6 [HSA:5687] [KO:K02730] TNFSF4 [HSA:7292] [KO:K05469] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Aspirin [DR:D00109] Clopidogrel bisulfate [DR:D00769] Prasugrel hydrochloride [DR:D05597] Ticagrelor [DR:D09017] Cangrelor tetrasodium [DR:D03361] Vorapaxar sulfate [DR:D09766] Reteplase [DR:D05721] Norepinephrine bitartrate [DR:D05206] Dopamine hydrochloride [DR:D00633] Nitroglycerin [DR:D00515] Niacin [DR:D00049] Propranolol hydrochloride [DR:D00483] Metoprolol tartrate [DR:D00601] Atenolol [DR:D00235] Lovastatin [DR:D00359] Atorvastatin calcium [DR:D02258] Alirocumab [DR:D10335] |
Comment | - |
Other DBs | ICD-11: BA41 ICD-10: I21 MeSH: D009203 OMIM: 608446 |
Reference | PMID:25638347 AUTHORS Lu L, Liu M, Sun R, Zheng Y, Zhang P TITLE Myocardial Infarction: Symptoms and Treatments. JOURNAL Cell Biochem Biophys 72:865-7 (2015) DOI:10.1007/s12013-015-0553-4 PMID:22922597 AUTHORS Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD TITLE Third universal definition of myocardial infarction. JOURNAL Nat Rev Cardiol 9:620-33 (2012) DOI:10.1038/nrcardio.2012.122 PMID:26426469 AUTHORS Frangogiannis NG TITLE Pathophysiology of Myocardial Infarction. JOURNAL Compr Physiol 5:1841-75 (2015) DOI:10.1002/cphy.c150006 PMID:22061094 (ESR1) AUTHORS Puzianowska-Kuznicka M TITLE ESR1 in myocardial infarction. JOURNAL Clin Chim Acta 413:81-7 (2012) DOI:10.1016/j.cca.2011.10.028 PMID:30972713 (F13A1) AUTHORS Ambroziak M, Kurylowicz A, Budaj A TITLE Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients. JOURNAL J Thromb Thrombolysis 48:519-527 (2019) DOI:10.1007/s11239-019-01856-3 PMID:10984565 (F7) AUTHORS Girelli D, Russo C, Ferraresi P, Olivieri O, Pinotti M, Friso S, Manzato F, Mazzucco A, Bernardi F, Corrocher R TITLE Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. JOURNAL N Engl J Med 343:774-80 (2000) DOI:10.1056/NEJM200009143431104 PMID:12598062 (GCLC) AUTHORS Koide S, Kugiyama K, Sugiyama S, Nakamura S, Fukushima H, Honda O, Yoshimura M, Ogawa H TITLE Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. JOURNAL J Am Coll Cardiol 41:539-45 (2003) DOI:10.1016/s0735-1097(02)02866-8 PMID:12081989 (GCLM) AUTHORS Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H, Honda O, Yoshimura M, Ogawa H TITLE Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction. JOURNAL Circulation 105:2968-73 (2002) DOI:10.1161/01.cir.0000019739.66514.1e PMID:31457051 (ITGB3) AUTHORS Sheikhvatan M, Boroumand MA, Behmanesh M, Ziaee S, Cheraghee S TITLE Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease. JOURNAL Iran J Biotechnol 17:e1921 (2019) DOI:10.21859/ijb.1921 PMID:34122585 (LRP8) AUTHORS Ghorbani MJ, Razmi N, Tabei SMB, Zibaeenezhad MJ, Goodarzi HR TITLE A substitution mutation in LRP8 gene is significantly associated with susceptibility to familial myocardial infarction. JOURNAL ARYA Atheroscler 16:301-305 (2020) DOI:10.22122/arya.v16i6.1797 PMID:12426569 (LTA) AUTHORS Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato H, Sato H, Hori M, Nakamura Y, Tanaka T TITLE Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. JOURNAL Nat Genet 32:650-4 (2002) DOI:10.1038/ng1047 PMID:12646194 (OLR1) AUTHORS Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, Kawana M, Masaki T, Kasanuki H, Sawamura T, Matsuoka R TITLE Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. JOURNAL Biochem Biophys Res Commun 303:247-50 (2003) DOI:10.1016/s0006-291x(03)00326-7 PMID:16845397 (PSMA6) AUTHORS Ozaki K, Sato H, Iida A, Mizuno H, Nakamura T, Miyamoto Y, Takahashi A, Tsunoda T, Ikegawa S, Kamatani N, Hori M, Nakamura Y, Tanaka T TITLE A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. JOURNAL Nat Genet 38:921-5 (2006) DOI:10.1038/ng1846 PMID:15750594 (TNFSF4) AUTHORS Wang X, Ria M, Kelmenson PM, Eriksson P, Higgins DC, Samnegard A, Petros C, Rollins J, Bennet AM, Wiman B, de Faire U, Wennberg C, Olsson PG, Ishii N, Sugamura K, Hamsten A, Forsman-Semb K, Lagercrantz J, Paigen B TITLE Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. JOURNAL Nat Genet 37:365-72 (2005) DOI:10.1038/ng1524 |