| H00008 | |
| H number | H00008 |
| Name | Burkitt lymphoma |
| Description | Burkitt lymphoma (BL) is a highly aggressive mature B-cell non-Hodgkin's lymphoma consisting of endemic, sporadic, and immunodeficiency-associated variants. Endemic BL (eBL) affects children and young adults in Africa and some other geographical areas and carries Epstein-Barr virus (EBV) in more than 95% of cases. In contrast, sporadic BL (sBL) among adolescents in Europe and North America are mostly EBV-negative. A third type of BL is associated with HIV-infection in adults. All of these subtypes possess chromosomal rearrangements of the c-myc oncogene, the genetic hallmark of BL that contributes to lymphomagenesis through alterations in cell cycle regulation, cellular differentiation, apoptosis, cellular adhesion, and metabolism. Many BL carry point mutation in the p53 tumor suppressor gene or other defects in the p14ARF-MDM2-p53 pathway, and inactivation of the p16INK4a gene by promoter methylation or homozygous deletion. This indicates that disruption of both the pRb and p53 tumor suppressor pathways is critical for BL development. |
| Category | Cancer |
| Network | nt06165 Epstein-Barr virus (EBV) nt06516(H00008) TNF signaling nt06517(H00008) TLR signaling nt06518(H00008) JAK-STAT signaling nt06519(H00008) RLR signaling nt06524(H00008) Apoptosis nt06528(H00008) Calcium signaling nt06530(H00008) PI3K signaling |
| Gene | MYC-IgH (translocation) [HSA:4609] [KO:K04377] p53 (mutation) [HSA:7157] [KO:K04451] p16/INK4A (promoter methylation) [HSA:1029] [KO:K06621] |
| Pathogen | Human herpesvirus 4 (Epstein-Barr virus) [GN:T40079] Human immunodeficiency virus 1 (HIV-1) [GN:T40001] |
| Env factor | - |
| Carcinogen | - |
| Drug | Cyclophosphamide [DR:D00287] Epcoritamab [DR:D12368] |
| Comment | - |
| Other DBs | ICD-11: 2A85.6 ICD-10: C83.7 MeSH: D002051 |
| Reference | PMID:12191637 AUTHORS Lindstrom MS, Wiman KG. TITLE Role of genetic and epigenetic changes in Burkitt lymphoma. JOURNAL Semin Cancer Biol 12:381-7 (2002) DOI:10.1016/S1044-579X(02)00058-5 PMID:15803153 AUTHORS Kuppers R. TITLE Mechanisms of B-cell lymphoma pathogenesis. JOURNAL Nat Rev Cancer 5:251-62 (2005) DOI:10.1038/nrc1589 PMID:16062089 AUTHORS Patel P, Moazzam N, Potti A, Mehdi SA. TITLE Azathioprine induced hodgkin lymphoma: a case report and review of literature. JOURNAL Am J Clin Oncol 28:427-8 (2005) DOI:10.1097/01.coc.0000168670.28659.8d PMID:15760280 AUTHORS Schottenfeld D, Beebe-Dimmer JL. TITLE Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. JOURNAL Annu Rev Public Health 26:37-60 (2005) DOI:10.1146/annurev.publhealth.26.021304.144402 PMID:15660110 AUTHORS Luch A. TITLE Nature and nurture - lessons from chemical carcinogenesis. JOURNAL Nat Rev Cancer 5:113-25 (2005) DOI:10.1038/nrc1546 PMID:12464351 AUTHORS Kolman A, Chovanec M, Osterman-Golkar S. TITLE Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001). JOURNAL Mutat Res 512:173-94 (2002) DOI:10.1016/S1383-5742(02)00067-4 PMID:17530489 AUTHORS Abnet CC. TITLE Carcinogenic food contaminants. JOURNAL Cancer Invest 25:189-96 (2007) DOI:10.1080/07357900701208733 |