| H00932 | |
| H number | H00932 |
| Name | Tropical calcific pancreatitis |
| Description | Tropical calcific pancreatitis (TCP) is a subtype of chronic pancreatitis unique to developing countries in tropical regions. Patients present with recurrent abdominal pain, nutritional deficiencies, and insulin-requiring diabetes resulting from chronic pancreatitis before age 30. Several environmental and genetic factors are implicated in TCP. |
| Category | Digestive system disease |
| Network | - |
| Gene | SPINK1 [HSA:6690] [KO:K23417] CTRC [HSA:11330] [KO:K01311] CTSB [HSA:1508] [KO:K01363] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: DC32.5 MeSH: C564276 OMIM: 608189 |
| Reference | PMID:18604651 AUTHORS Witt H, Bhatia E TITLE Genetic aspects of tropical calcific pancreatitis. JOURNAL Rev Endocr Metab Disord 9:213-26 (2008) DOI:10.1007/s11154-008-9088-y PMID:21323990 AUTHORS Reddy DN, Prasad SS TITLE Genetic basis of chronic pancreatitis in Asia Pacific region. JOURNAL J Gastroenterol Hepatol 26 Suppl 2:2-5 (2011) DOI:10.1111/j.1440-1746.2010.06598.x PMID:12011155 (SPINK1) AUTHORS Chandak GR, Idris MM, Reddy DN, Bhaskar S, Sriram PV, Singh L TITLE Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. JOURNAL J Med Genet 39:347-51 (2002) DOI:10.1136/jmg.39.5.347 PMID:18059268 (CTRC) AUTHORS Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvari B, Landt O, Schulz HU, Gress TM, Pfutzer R, Lohr M, Kovacs P, Bluher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M Jr, Puhl G, Witt U, Schmidt H, Buning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bodeker H, Keim V, Mossner J, Teich N, Sahin-Toth M TITLE Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. JOURNAL Nat Genet 40:78-82 (2008) DOI:10.1038/ng.2007.44 PMID:16492714 (CTSB) AUTHORS Mahurkar S, Idris MM, Reddy DN, Bhaskar S, Rao GV, Thomas V, Singh L, Chandak GR TITLE Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. JOURNAL Gut 55:1270-5 (2006) DOI:10.1136/gut.2005.087403 |