| H01321 | |
| H number | H01321 |
| Name | Pneumococcal disease |
| Description | Pneumococcal disease (PD) is infectious disease caused by Streptococcus pneumoniae (pneumococcus). PD is particularly common in younger children and in older adults and is roughly divided into invasive and non-invasive disease; the former refers to infections in which the microorganism is isolated from normal sterile body sites, such as the blood or the cerebrospinal fluid. Non-invasive PD can principally be divided into sinusitis, acute otitis media, and community-acquired pneumonia. S. pneumoniae remains the most common bacterial cause of community-acquired pneumonia. The invasive PD burden is mainly determined by pneumococcal meningitis, bacteremic pneumococcal pneumonia, and pneumococcal bacteremia without a primary focus. Incidence and mortality rates of both non-invasive and invasive disease have changed as a result of pneumococcal vaccination in children. However, especially elderly patients with comorbidities remain vulnerable to morbidity and mortality caused by PD. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Streptococcus pneumoniae [GN:spn spd spw spx snd spnn sne spng snp spnm spno] |
| Env factor | - |
| Carcinogen | - |
| Drug | Penicillin G potassium [DR:D01053] Pneumococcal vaccine polyvalent [DR:D08776] Pneumococcal 13-valent conjugate vaccine [DR:D10455] Pneumococcal 15-valent conjugate vaccine [DR:D12205] Pneumococcal 20-valent conjugate vaccine [DR:D12207] |
| Comment | - |
| Other DBs | ICD-11: CA40.07 ICD-10: A40.3 A49.1 MeSH: D011008 |
| Reference | PMID:24313448 AUTHORS Drijkoningen JJ, Rohde GG TITLE Pneumococcal infection in adults: burden of disease. JOURNAL Clin Microbiol Infect 20 Suppl 5:45-51 (2014) DOI:10.1111/1469-0691.12461 PMID:25343039 AUTHORS Feldman C, Anderson R TITLE Recent advances in our understanding of Streptococcus pneumoniae infection. JOURNAL F1000Prime Rep 6:82 (2014) DOI:10.12703/P6-82 |