| H01333 | |
| H number | H01333 |
| Name | Non-alcoholic fatty liver disease |
| Description | It has been reported that those patients with non-alcoholic fatty liver disease (NAFLD) are probably more common in those individuals with metabolic syndrome, which includes obesity and type 2 diabetes mellitus. The spectrum of NAFLD ranges from simple steatosis to steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). Of those with NASH, approximately 20% will go on to develop cirrhosis and hepatocellular carcinoma. |
| Category | Digestive system disease DIS_PATHWAY hsa04932 Non-alcoholic fatty liver disease |
| Network | - |
| Gene | PNPLA3(polymorphism) [HSA:80339] [KO:K13534] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: DB92 ICD-10: K75.8 K76.0 |
| Reference | PMID:20373368 AUTHORS Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, Nobili V, Mozzi E, Roviaro G, Vanni E, Bugianesi E, Maggioni M, Fracanzani AL, Fargion S, Day CP TITLE Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. JOURNAL Hepatology 51:1209-17 (2010) DOI:10.1002/hep.23622 PMID:20684021 AUTHORS Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ TITLE The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. JOURNAL Hepatology 52:894-903 (2010) DOI:10.1002/hep.23759 PMID:20648472 AUTHORS Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN TITLE PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. JOURNAL Hepatology 52:904-12 (2010) DOI:10.1002/hep.23768 |