| H01639 | |
| H number | H01639 |
| Name | Endometriosis |
| Description | Endometriosis is defined as the growth of the endometrial glands and stroma at extra-uterine sites, which are most commonly implanted over and under visceral and peritoneal surfaces within the female pelvis but which can also be found in the connective tissue in the pelvis areas and, more rarely, in any anatomic district. It is a major cause of infertility, dysmenorrhea, dyspareunia, and chronic pelvic pain, mediated by marked pelvic inflammation. While retrograde menstruation is the most widely accepted cause, its pathogenesis and natural course are not fully understood. Endometriosis is known to be an estrogen-dependent disease, manifests during reproductive years. |
| Category | Reproductive system disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Medroxyprogesterone acetate [DR:D00951] Danazol [DR:D00289] Nafarelin acetate [DR:D00990] Elagolix sodium [DR:D09336] Leuprolide acetate [DR:D00989] Goserelin acetate [DR:D00573] |
| Comment | - |
| Other DBs | ICD-11: GA10 ICD-10: N80 MeSH: D004715 |
| Reference | PMID:24927773 AUTHORS Aznaurova YB, Zhumataev MB, Roberts TK, Aliper AM, Zhavoronkov AA TITLE Molecular aspects of development and regulation of endometriosis. JOURNAL Reprod Biol Endocrinol 12:50 (2014) DOI:10.1186/1477-7827-12-50 PMID:24366116 AUTHORS Vercellini P, Vigano P, Somigliana E, Fedele L TITLE Endometriosis: pathogenesis and treatment. JOURNAL Nat Rev Endocrinol 10:261-75 (2014) DOI:10.1038/nrendo.2013.255 PMID:26125255 AUTHORS Soave I, Caserta D, Wenger JM, Dessole S, Perino A, Marci R TITLE Environment and Endometriosis: a toxic relationship. JOURNAL Eur Rev Med Pharmacol Sci 19:1964-72 (2015) |