| H01690 | |
| H number | H01690 |
| Name | Lichen sclerosus et atrophicus |
| Description | Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatitis affecting primarily vulvar, perianal and perineal skin. Extragenital lichen sclerosus is most common on the neck, shoulders, and upper portion of the trunk. It is generally asymptomatic or is occasionally pruritic and presents as flat, white, polygonal papules and atrophic white plaques. It is primarily seen in postmenopausal women, but also men and children can be affected. The aetiology is not clearly established, although there is a strong association with autoimmune diseases. Morphea may coexist with LSA. Standard treatment includes topical corticosteroid and calcineurin inhibitors, such as tacrolimus. The association between LSA and squamous cell carcinoma (SCC) is confirmed and has been described chiefly in females. The risk of SCC of the vulva has been estimated to about 5% in women with LSA. |
| Category | Immune system disease; Skin disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | See also H01493 Localized Scleroderma. |
| Other DBs | ICD-11: EB60 ICD-10: L90.0 MeSH: D008011 OMIM: 151590 |
| Reference | PMID:26500867 AUTHORS Diwan NG, Nair PA TITLE Extragenital lichen sclerosus et atrophicus along the lines of Blaschko. JOURNAL Indian Dermatol Online J 6:342-4 (2015) DOI:10.4103/2229-5178.164486 PMID:24470666 AUTHORS Kar BR, Dash K TITLE Co-existence of Lichen Sclerosus et Atrophicus and Morphoea Along Lines of Blaschko. JOURNAL Indian J Dermatol 59:77-9 (2014) DOI:10.4103/0019-5154.123507 PMID:24549239 AUTHORS Kantere D, Lowhagen GB, Alvengren G, Maneskold A, Gillstedt M, Tunback P TITLE The clinical spectrum of lichen sclerosus in male patients - a retrospective study. JOURNAL Acta Derm Venereol 94:542-6 (2014) DOI:10.2340/00015555-1797 |