H01701 | |
H number | H01701 |
Name | Pituitary TSH hypersecretion; Syndrome of inappropriate secretion of TSH (SITSH) |
Description | Pituitary TSH hypersecretion is disease of the anterior portion of the pituitary resulting in hypersecretion of thyroid stimulating hormone (TSH). It includes two forms of central hyperthyroidism, i.e. TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone action (RTH). The incidence of hyperthyroidism due to a TSHoma is extremely low, 1-2% of all cases of hyperthyroidism. Most of the tumors are macroadenomas usually presenting with symptoms such as headache and/or visual field impairment while the symptoms of hyperthyroidism seem to be milder compared with those caused by primary hyperthyroidism. First-line treatment of TSHoma is pituitary adenomectomy followed by irradiation in the case of surgical failure. However, medical treatment with somatostatin analogs, such as octreotide and lanreotide, are effective in reducing TSH secretion. |
Category | Endocrine and metabolic disease |
Network | - |
Gene | - |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | See also H00249 Thyroid hormone resistance syndrome, H01102 Pituitary adenomas, and H01645 Hyperthyroidism. |
Other DBs | ICD-11: 5A60.Y ICD-10: E22.9 MeSH: D006964 |
Reference | PMID:25905212 AUTHORS Beck-Peccoz P, Persani L, Lania A TITLE Thyrotropin-Secreting Pituitary Adenomas JOURNAL Endotext (2000) PMID:23402621 AUTHORS Tong A, Xia W, Qi F, Jin Z, Yang D, Zhang Z, Li F, Xing X, Lian X TITLE Hyperthyroidism caused by an ectopic thyrotropin-secreting tumor of the nasopharynx: a case report and review of the literature. JOURNAL Thyroid 23:1172-7 (2013) DOI:10.1089/thy.2012.0574 PMID:26765410 AUTHORS Mousiolis AC, Rapti E, Grammatiki M, Yavropoulou M, Efstathiou M, Foroglou N, Daniilidis M, Kotsa K TITLE Somatostatin Analogue Treatment of a TSH-Secreting Adenoma Presenting With Accelerated Bone Metabolism and a Pericardial Effusion: A Case Report. JOURNAL Medicine (Baltimore) 95:e2358 (2016) DOI:10.1097/MD.0000000000002358 PMID:24783044 AUTHORS Beck-Peccoz P, Lania A, Beckers A, Chatterjee K, Wemeau JL TITLE 2013 European thyroid association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors. JOURNAL Eur Thyroid J 2:76-82 (2013) DOI:10.1159/000351007 |