| H01726 | |
| H number | H01726 |
| Name | Membranoproliferative glomerulonephritis |
| Description | Membranoproliferative glomerulonephritis (MPGN) represents a pattern of glomerular injury, characterized by mesangial proliferation and expansion, lobularization of the glomerular tufts, and double contours. Classification of MPGN has been updated in the 2010s and is now categorized according to the immunofluorescence microscopy findings. MPGN is now recognized as follows: Immunocomplexes-associated MPGN with complement over activation; MPGN with intramembranous dense deposits; and C3 glomerulopathy. |
| Category | Immune system disease; Urinary system disease |
| Network | - |
| Gene | CFH [HSA:3075] [KO:K04004] CFHR5 [HSA:81494] [KO:K23817] DGKE [HSA:8526] [KO:K00901] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: MF8Y ICD-10: N03 MeSH: D015432 OMIM: 609814 614809 615008 |
| Reference | PMID:27356907 AUTHORS Lionaki S, Gakiopoulou H, Boletis JN TITLE Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. JOURNAL APMIS 124:725-35 (2016) DOI:10.1111/apm.12566 PMID:27458560 AUTHORS Salvadori M, Rosso G TITLE Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. JOURNAL World J Nephrol 5:308-20 (2016) DOI:10.5527/wjn.v5.i4.308 PMID:26921911 AUTHORS Floege J, Amann K TITLE Primary glomerulonephritides. JOURNAL Lancet 387:2036-48 (2016) DOI:10.1016/S0140-6736(16)00272-5 |