| H01899 | |
| H number | H01899 |
| Name | Dyslexia |
| Description | Dyslexia is defined by severe difficulties in reading acquisition, often accompanied by spelling difficulties and affects a large number of people (5-10%). It is caused by multiple genetic and environmental risk factors as well as their interplay. Several candidate genes have been identified in the past decade. However, effects of individual genetic variations on dyslexia-associated deficits are only moderate. At the brain level, dyslexia is associated with aberrant structure and function, particularly in left hemisphere reading-language networks. |
| Category | Mental and behavioural disorder |
| Network | - |
| Gene | (DYX1) DNAAF4 [HSA:161582] [KO:K19758] (DYX2) AAVR [HSA:9856] [KO:K24403] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: MB4B.0 ICD-10: R48.0 MeSH: D004410 OMIM: 127700 600202 |
| Reference | PMID:25594880 AUTHORS Peterson RL, Pennington BF TITLE Developmental dyslexia. JOURNAL Annu Rev Clin Psychol 11:283-307 (2015) DOI:10.1146/annurev-clinpsy-032814-112842 PMID:20862559 AUTHORS Svensson I, Nilsson S, Wahlstrom J, Jernas M, Carlsson LM, Hjelmquist E TITLE Familial dyslexia in a large Swedish family: a whole genome linkage scan. JOURNAL Behav Genet 41:43-9 (2011) DOI:10.1007/s10519-010-9395-4 PMID:17111266 AUTHORS Shastry BS TITLE Developmental dyslexia: an update. JOURNAL J Hum Genet 52:104-9 (2007) DOI:10.1007/s10038-006-0088-z PMID:26283516 AUTHORS Mannel C, Meyer L, Wilcke A, Boltze J, Kirsten H, Friederici AD TITLE Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype. JOURNAL Cortex 71:291-305 (2015) DOI:10.1016/j.cortex.2015.06.029 PMID:12954984 (DYX1) AUTHORS Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T, Myllyluoma B, Lyytinen H, Muller K, Kaaranen M, Lindsberg PJ, Hannula-Jouppi K, Kere J TITLE A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. JOURNAL Proc Natl Acad Sci U S A 100:11553-8 (2003) DOI:10.1073/pnas.1833911100 PMID:15717286 (DYX2) AUTHORS Cope N, Harold D, Hill G, Moskvina V, Stevenson J, Holmans P, Owen MJ, O'Donovan MC, Williams J TITLE Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. JOURNAL Am J Hum Genet 76:581-91 (2005) DOI:10.1086/429131 |