| H01037 | |
| H number | H01037 |
| Name | Vesicoureteral reflux |
| Description | Vesicoureteral reflux (VUR) is the abnormal retrograde urinary flow from the bladder to the kidney that affects approximately 1% of the general population. It is associated with an increased risk of recurrent urinary tract infection, pyelonephritis, and renal scarring. |
| Category | Urinary system disease |
| Network | - |
| Gene | (VUR2) ROBO2 [HSA:6092] [KO:K06754] (VUR3) SOX17 [HSA:64321] [KO:K04495] (VUR8) TNXB [HSA:7148] [KO:K06252] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: GB56.5 ICD-10: N13.7 MeSH: D014718 OMIM: 610878 613674 615963 |
| Reference | PMID:22264440 AUTHORS Routh JC, Bogaert GA, Kaefer M, Manzoni G, Park JM, Retik AB, Rushton HG, Snodgrass WT, Wilcox DT TITLE Vesicoureteral reflux: current trends in diagnosis, screening, and treatment. JOURNAL Eur Urol 61:773-82 (2012) DOI:10.1016/j.eururo.2012.01.002 PMID:21862976 AUTHORS Puri P, Gosemann JH, Darlow J, Barton DE TITLE Genetics of vesicoureteral reflux. JOURNAL Nat Rev Urol 8:539-52 (2011) DOI:10.1038/nrurol.2011.113 PMID:21475075 AUTHORS Carvas F, Silva A, Nguyen HT TITLE The genetics of primary, nonsyndromic vesicoureteral reflux. JOURNAL Curr Opin Urol 20:336-42 (2010) DOI:10.1097/MOU.0b013e328339b739 PMID:17357069 (ROBO2) AUTHORS Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL TITLE Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. JOURNAL Am J Hum Genet 80:616-32 (2007) DOI:10.1086/512735 PMID:20960469 (SOX17) AUTHORS Gimelli S, Caridi G, Beri S, McCracken K, Bocciardi R, Zordan P, Dagnino M, Fiorio P, Murer L, Benetti E, Zuffardi O, Giorda R, Wells JM, Gimelli G, Ghiggeri GM TITLE Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract. JOURNAL Hum Mutat 31:1352-9 (2010) DOI:10.1002/humu.21378 PMID:23620400 (TNXB) AUTHORS Gbadegesin RA, Brophy PD, Adeyemo A, Hall G, Gupta IR, Hains D, Bartkowiak B, Rabinovich CE, Chandrasekharappa S, Homstad A, Westreich K, Wu G, Liu Y, Holanda D, Clarke J, Lavin P, Selim A, Miller S, Wiener JS, Ross SS, Foreman J, Rotimi C, Winn MP TITLE TNXB mutations can cause vesicoureteral reflux. JOURNAL J Am Soc Nephrol 24:1313-22 (2013) DOI:10.1681/ASN.2012121148 |