| H01039 | |
| H number | H01039 |
| Name | Ovarian hyperstimulation syndrome |
| Description | Ovarian hyperstimulation syndrome (OHSS) is typically an iatrogenic complication of ovulation induction (OI) occurring during the luteal phase or early pregnancy. OHSS is characterised by a cystic enlargement of the ovaries and an acute fluid shift from the intravascular to the third space, which may result in ascites, pleural infusions, pericardial infusion, and even generalized edema. Majority of OHSS cases have been associated with the use of gonadotrophins for OI in anovulatory women or for ovarian stimulation (OS) in the context of assisted reproductive technology (ART). Recurrent cases and familial occurrence of OHSS have been described, and different mutations in the follicle-stimulating hormone receptor (FSHr) have been reported in these cases. Polycystic ovarian syndrome (PCOS) appears to be the major predisposing factor for OHSS in a large number of studies. |
| Category | Reproductive system disease |
| Network | - |
| Gene | FSHR [HSA:2492] [KO:K04247] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | - |
| Other DBs | ICD-11: GA32.0 ICD-10: N98.1 MeSH: D016471 OMIM: 608115 |
| Reference | PMID:20977119 AUTHORS Kasum M TITLE New insights in mechanisms for development of ovarian hyperstimulation syndrome. JOURNAL Coll Antropol 34:1139-43 (2010) PMID:19632900 AUTHORS Vloeberghs V, Peeraer K, Pexsters A, D'Hooghe T TITLE Ovarian hyperstimulation syndrome and complications of ART. JOURNAL Best Pract Res Clin Obstet Gynaecol 23:691-709 (2009) DOI:10.1016/j.bpobgyn.2009.02.006 PMID:20416867 AUTHORS Humaidan P, Quartarolo J, Papanikolaou EG TITLE Preventing ovarian hyperstimulation syndrome: guidance for the clinician. JOURNAL Fertil Steril 94:389-400 (2010) DOI:10.1016/j.fertnstert.2010.03.028 PMID:17055817 TITLE Ovarian hyperstimulation syndrome. JOURNAL Fertil Steril 86:S178-83 (2006) DOI:10.1016/j.fertnstert.2006.08.021 |