| H01154 | |
| H number | H01154 |
| Name | Wolff-Parkinson-White (WPW) syndrome; Preexcitation syndrome |
| Description | Wolff-Parkinson-White (WPW) syndrome is the most common cause of ventricular pre-excitation, a condition where all or part of the ventricle is excited earlier than would normally be expected, often leading to ventricular fibrillation and sudden cardiac death. It was recently discovered that mutations in PRKAG2, that encodes a subunit of the AMP-activated protein kinase, is responsible for WPW syndrome. |
| Category | Cardiovascular disease |
| Network | - |
| Gene | PRKAG2 [HSA:51422] [KO:K07200] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | The use of Verapamil [DG:DG00329] or Digoxin [DR:D00298] for long-term therapy appears to be contraindicated for many patients with WPW syndrome. |
| Other DBs | ICD-11: BC81.4 ICD-10: I45.6 OMIM: 194200 |
| Reference | PMID:20888928 AUTHORS Sternick EB, Oliva A, Gerken LM, Magalhaes L, Scarpelli R, Correia FS, Rego S, Santana O, Brugada R, Wellens HJ TITLE Clinical, electrocardiographic, and electrophysiologic characteristics of patients with a fasciculoventricular pathway: the role of PRKAG2 mutation. JOURNAL Heart Rhythm 8:58-64 (2011) DOI:10.1016/j.hrthm.2010.09.081 PMID:16686673 AUTHORS Light PE TITLE Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? JOURNAL J Cardiovasc Electrophysiol 17 Suppl 1:S158-S161 (2006) DOI:10.1111/j.1540-8167.2006.00399.x PMID:15952923 AUTHORS Redfearn DP, Krahn AD, Skanes AC, Yee R, Klein GJ TITLE Use of medications in Wolff-Parkinson-White syndrome. JOURNAL Expert Opin Pharmacother 6:955-63 (2005) DOI:10.1517/14656566.6.6.955 PMID:17547624 (Drug) AUTHORS Fragakis N, Iliadis I, Papanastasiou S, Lambrou A, Katsaris G TITLE Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome. JOURNAL Pacing Clin Electrophysiol 30:823-5 (2007) DOI:10.1111/j.1540-8159.2007.00762.x |