| H00297 | |
| H number | H00297 |
| Name | Plague |
| Description | Plague is a deadly infectious disease caused by Yersinia pestis. The pathogen has rodent reservoirs and is transmitted to humans usually by fleas as vectors. There are three major manifestations: bubonic, septicemic, and pneumonic plagues. Severe epidemics in the past include the Plague of Justinian in the sixth century, the Black Death in the fourteenth century, and the Third Pandemic that began in Central Asia in the nineteenth century. The genome sequences have been determined for the strains responsible for these epidemics. |
| Category | Bacterial infectious disease |
| Network | nt06517(H00297) TLR signaling nt06521(H00297) NLR signaling nt06528(H00297) Calcium signaling |
| Gene | - |
| Pathogen | Yersinia pestis CO92 (biovar Orientalis) [GN:ype] (Third Pandemic) Yersinia pestis KIM (biovar Mediaevalis) [GN:ypk] (Black Death) Yersinia pestis Antiqua,Nepal516 (biovar Antiqua) [GN:ypa ypn] (Plague of Justinian) Yersinia pestis Pestoides F [GN:ypp] Yersinia pestis Angola [GN:ypg] Yersinia pestis D106004 [GN:ypd] Yersinia pestis D182038 [GN:ypx] |
| Env factor | - |
| Carcinogen | - |
| Drug | Tetracycline hydrochloride [DR:D02122] Doxycycline [DR:D00307] Doxycycline hyclate [DR:D02129] Doxycycline calcium [DR:D03903] Minocycline hydrochloride [DR:D00850] Streptomycin sulfate [DR:D01350] Demeclocycline hydrochloride [DR:D00290] Ciprofloxacin [DR:D00186] Ciprofloxacin hydrochloride [DR:D02216] Levofloxacin [DR:D00588] Moxifloxacin hydrochloride [DR:D00874] |
| Comment | Vector: Xenopsylla cheopis (rat flea) murine toxin [KO:K11009] |
| Other DBs | ICD-11: 1B93 ICD-10: A20 MeSH: D010930 MedlinePlus: 000596 |
| Reference | - |