|Name||Haemophilus influenzae infection|
|Description||Haemophilus influenzae type b (Hib) infections are a major cause of severe infections in children between 2 months and 5 years of age worldwide. It affects approximately 25000 patients each year. Severity of the symptoms of Hib infection depends on the patient's age, and infants between 4 months and 1 year of age are at highest risk for meningitis. Invasive disease due to Hib may produce various clinical syndromes including meningitis, arthritis, pneumonia, cellulitis, osteomyelitis, and epiglottitis. Mucosal infections, such as bronchitis, sinusitis and conjunctivitis, and otitis media, can also be caused by Hib, but they are considered to be noninvasive disease.|
|Pathogen||Haemophilus influenzae [GN:hin hit hip hiq hiu hik]|
|Drug||Third-generation cephalosporins [DG:DG00570 DG00573]
Comination of ampicillin and chloramphenicol [DG:DG00517 DG00399]
Rifampicin (prophylaxis) [DG:DG00639]
Hib conjugate vaccine [DR:D09189]
|Comment||American Indians and Alaskan Eskimos are at increased risk specifically for meningitis caused by Hib.|
|Other DBs||ICD-10: A41.3 A49.2 G00.0 J14 J20.1
|Reference||PMID:2194406 (description, drug, comment)
Janai H, Stutman HR, Marks MI
Invasive Haemophilus influenzae type B infections: a continuing challenge.
Am J Infect Control 18:160-6 (1990)
Two decades of experience with the Haemophilus influenzae serotype b conjugate vaccine in the United Kingdom.
Clin Ther 34:385-99 (2012)
Fitzwater SP, Watt JP, Levine OS, Santosham M
Haemophilus influenzae type b conjugate vaccines: considerations for vaccination schedules and implications for developing countries.
Hum Vaccin 6:810-8 (2010)
Epidemiology and prevention of invasive Haemophilus influenzae type b infection.
Aust Paediatr J 23:323-7 (1987)