Life science projects in Japan
Former name: Genome, post genome projects in Japan
| Development of Basic Technology for Protein Structure Analysis Aimed at Acceleration of Drug Discovery Research | |
| Project Name | Development of Basic Technology for Protein Structure Analysis Aimed at Acceleration of Drug Discovery Research |
| Start Year | 2007 |
| End Year | 2011 |
| Implementing Period | 2007-2011 |
| Budget Amount | 933 million yen (2007) |
| Major Researchers | Chief Researcher: Ichio Shimada (University of Tokyo Graduate School of Pharmaceutical Sciences) Other Leading Researchers: Yoshinori Fujiyoshi (Kyoto University Graduate School of Science) Haruki Nakamura (Osaka University - Institute for Protein Research) |
| Summary | Determination of three-dimensional structure and function for membrane proteins and related protein complexes |
| Major Features of Project | Development of advanced fundamental technologies that enable analysis of the three-dimensional structural information and the interaction information of membrane proteins and its complexes at the cell cortex as well as high-precision in silico screening and other types of simulation |
| Description of Project | Excerpts from "Structural-guided Drug Development" on JBiC web site ( http://www.jbic.or.jp/bio/english/activity/d_dvl_pj/index_dd.html ): 1. Development of structural analysis technology Development of analytical tools/techniques for resolving the conformations of real membrane proteins and their complexes on the cell membrane 2. Development of interaction analysis technology Development of analytical tools/techniques for resolving the structure of interactive sites between real membrane proteins and their complexes on the cell membrane and their ligands 3. Development of simulation technology Development of high-precision in silico screening and modeling technologies based on the analytical data obtained through 1 and 2 |
| Public Release Status | The project just started in 2007. Development of methods and results of individual analyses are the expected major outcomes. |
| Classification of Database Public Release Status | Unpublished |
| Public Database | - |
| Data Download Site | - |
| Website | JBiC: http://www.jbic.or.jp/bio/english/activity/chem-bio/index_ch.html |
| Implementing Ministry/Agency | Ministry of Economy, Trade and Industry (METI) |
| Commercialization Re | NA |
| Reports | - |
| Evaluation Reports | - |
| Other Literatures | "An interview with Ichio Shimada," JBiC JOURNAL 2007 APRIL. FY2007 Activity Plan ( http://www.jbic.or.jp/bio/c/files/jrnl0704.pdf , Japanese) "Outline of NEDO 2008-2009": http://www.nedo.go.jp/kankobutsu/pamphlets/kouhou/2007gaiyo_e/index.htm |