Life science projects in Japan

Former name: Genome, post genome projects in Japan


Development of Basic Technology for Protein Structure Analysis Aimed at Acceleration of Drug Discovery Research
Project Name Development of Basic Technology for Protein Structure Analysis Aimed at Acceleration of Drug Discovery Research
Start Year 2007
End Year 2011
Implementing Period 2007-2011
Budget Amount 933 million yen (2007)
Major Researchers Chief Researcher: Ichio Shimada (University of Tokyo Graduate School of Pharmaceutical Sciences)
Other Leading Researchers:
Yoshinori Fujiyoshi (Kyoto University Graduate School of Science)
Haruki Nakamura (Osaka University - Institute for Protein Research)
Summary Determination of three-dimensional structure and function for membrane proteins and related protein complexes
Major Features of Project Development of advanced fundamental technologies that enable analysis of the three-dimensional structural information and the interaction information of membrane proteins and its complexes at the cell cortex as well as high-precision in silico screening and other types of simulation

Description of Project Excerpts from "Structural-guided Drug Development" on JBiC web site ( http://www.jbic.or.jp/bio/english/activity/d_dvl_pj/index_dd.html ):

1. Development of structural analysis technology
Development of analytical tools/techniques for resolving the conformations of real membrane proteins and their complexes on the cell membrane
2. Development of interaction analysis technology
Development of analytical tools/techniques for resolving the structure of interactive sites between real membrane proteins and their complexes on the cell membrane and their ligands
3. Development of simulation technology
Development of high-precision in silico screening and modeling technologies based on the analytical data obtained through 1 and 2
Public Release Status The project just started in 2007. Development of methods and results of individual analyses are the expected major outcomes.
Classification of Database Public Release Status Unpublished
Public Database -
Data Download Site -
Website JBiC: http://www.jbic.or.jp/bio/english/activity/chem-bio/index_ch.html
Implementing Ministry/Agency Ministry of Economy, Trade and Industry (METI)
Reports -
Evaluation Reports -
Other Literatures "An interview with Ichio Shimada," JBiC JOURNAL 2007 APRIL.
FY2007 Activity Plan ( http://www.jbic.or.jp/bio/c/files/jrnl0704.pdf , Japanese)
"Outline of NEDO 2008-2009": http://www.nedo.go.jp/kankobutsu/pamphlets/kouhou/2007gaiyo_e/index.htm