Life science projects in Japan
Former name: Genome, post genome projects in Japan
| Structural Proteomics Project | |
| Project Name | Structural Proteomics Project |
| Start Year | 2002 |
| End Year | 2006 |
| Implementing Period | 2002-2006, Completed |
| Budget Amount | Total Amount: 6.894 billion yen |
| Major Researchers | Chief Researcher: Yoshimasa Kyogoku (Advanced Industrial Science and Technology - Biological Information Research Center) later succeeded by Ichio Shimada (University of Tokyo Graduate School of Pharmaceutical Sciences) Other leading researchers: - Yoshinori Fujiyoshi (Kyoto University Graduate School of Science) - Haruki Nakamura (Osaka University - Institute for Protein Research) |
| Summary | Structural Proteomics Project for Membrane Proteins and its Related Proteins |
| Major Features of Project | From the Basic Plan for "Structural Proteomics Project " ( http://www.nedo.go.jp/activities/portal/gaiyou/p02027/h18kihon.pdf , Japanese) This project focused on membrane proteins and related protein complexes that are likely to be identified as drug targets, and clarified the atomic-level three-dimensional structure and interactions in order to elucidate functional expression. (1) Development of electron- and X-ray-based technologies to analyze structure and molecular mechanism of membrane protein and other molecules as well as acquisition of data (2) Development of NMR-based technologies to analyze interactions between membrane-related proteins and between such proteins and other molecules as well as acquisition of data (3) Development of technologies to analyze structures, molecular mechanisms and biological functions of the complexes of membrane protein-related molecules (including proteins, nucleic acids, lipids and polysaccharides) as well as acquisition of data (4) Development of technologies to analyze structural information using database and simulation calculation |
| Description of Project | Excerpts from the Structural Proteomics Project(NEDO) (http://www.nedo.go.jp/english/activities/portal/gaiyou/p02027/p02027.html ): This project focuses on membrane proteins and related protein complexes that are very likely to be a drug treatment target. In order to elucidate atomic-level three-dimensional structures, interactions and functioning mechanisms of membrane proteins and related protein complexes, NEDO is utilizing cryoelectron microscopy, X-ray crystal analysis and nuclear magnetic resonance (NMR). The project also includes research to develop a single particle analysis method using a cryoelectron microscope, a tomography analysis method, and a novel NMR method for interaction analysis of polymeric proteins. These new methods will help to obtain information closer to actual systems, which is necessary for the practical application of structural proteomics technology. To predict a variety of functional structures with information regarding three-dimensional structure, we are also developing high-precision modeling and simulation technologies. Through this effort, this project aims to create an overall fundamental technology relating to bioinformatics, which is becoming an important field for making advances in genome science. By applying these newly developed technologies to the structural analysis of membrane proteins and other protein complexes, it will be possible to perform effective screening. The results of the project will be used to develop drugs with revolutionary functions and create new industry in related areas. |
| Public Release Status | Development of methods and results of individual analyses are the major outcomes. A molecular simulation system for protein and other molecules: PrestoX (later renamed myPresto) is available for download. myPresto: http://www.jbic.or.jp/bio/english/activity/st_pr_pj/mypresto/index_mp.html |
| Classification of Database Public Release Status | Partially publicly released |
| Public Database | - |
| Data Download Site | - |
| Website | - Project Portal Site (NEDO)( http://www.nedo.go.jp/activities/portal/p02027.html ) - Project Introduction Page (JBIC)( http://www.jbic.or.jp/bio/english/bio_e/sub_rd_p/prtomcsp.html ) |
| Implementing Ministry/Agency | Ministry of Economy, Trade and Industry (METI) |
| Commercialization Re | NA |
| Reports | The report may be obtained at the NEDO Outcome Report website( http://app3.infoc.nedo.go.jp/informations/koubo/databaselist ) by running a search by using the project name "Structural Proteomics Project for Membrane Proteins and its Related Proteins" as the keyword. |
| Evaluation Reports | - |
| Other Literatures | For the list of literatures concerning this project, see the Report of Research Project Results. |