Life science projects in Japan
Former name: Genome, post genome projects in Japan
| Toxicogenomics Informatics Project (TGP2) | |
| Project Name | Toxicogenomics Informatics Project (TGP2) |
| Start Year | 2007 |
| End Year | - |
| Implementing Period | 2007- |
| Budget Amount | - |
| Major Researchers | Chief Researcher: Yasuo Ohno (National Institute of Biomedical Innovation) Major Research Institutes: National Institute of Biomedical Innovation and 13 pharmaceutical companies. |
| Summary | Sequencing of rice genome and elucidation of gene functions |
| Major Features of Project | - This project is continuation of the TGP. In this project, which has the purpose of improving the efficiency of preclinical and clinical tests through improved extrapolation to human, the research on safety biomarkers based on mechanisms (of action) and the research to bridge animal and human will be implemented, and the establishment of the foundation for regulatory science will be promoted. - National Institute of Biomedical Innovation (independent administrative institution), National Institute of Health Sciences and 13 pharmaceutical companies. - Research on safety biomarkers based on mechanisms (of action) - Research to bridge animal and human - Establishment of the foundation for regulatory science - Enhancement of the contents of toxicogenomics system TG-GATEs |
| Description of Project | Excerpts from the Toxicogenomics Informatics Project (TGP2) website( http://wwwtgp.nibio.go.jp/index.html , Japanese ): Aiming to build on these research achievements, the National Institute of Biomedical Innovation, the National Institute of Health Sciences and thirteen pharmaceutical companies have started the Toxicogenomics Informatics Project (TGP2), which is continuation of the TGP. In this project, which has the purpose of improving the efficiency of preclinical and clinical tests, the research on safety biomarkers based on (toxic) mechanisms, the research to improve extrapolation to human, and the establishment of the foundation for regulatory science will be promoted. |
| Public Release Status | Currently, in principle the data are released to consortium members only, but as an exception some data are also publicly released. Timing and extent of the public release of the remaining data are unknown. |
| Classification of Database Public Release Status | Partially publicly released,Shared within consortium |
| Public Database | - |
| Data Download Site | - |
| Website | Toxicogenomics Informatics Project (TGP2) website ( http://wwwtgp.nibio.go.jp/index.html , Japanese) |
| Implementing Ministry/Agency | Ministry of Health, Labour and Welfare(MHLW) |
| Commercialization Re | From the Toxicogenomics Informatics Project (TGP2) website: Participating Organizations: -National Institute of Biomedical Innovation -National Institute of Health Sciences -Astellas Pharma Inc. -Eisai Co., Ltd. -Otsuka Pharmaceutical Co., Ltd. -Ono Pharmaceutical Co., Ltd. -Kissei Pharmaceutical Co., Ltd. -Sanwa Kagaku Kenkyusho Co., Ltd. -Shionogi & Co., Ltd. -Daiichi Sankyo Co., Ltd. -Dainippon Sumitomo Pharma Co., Ltd. -Takeda Pharmaceutical Co., Ltd. -Mitsubishi Tanabe Pharma Corporation -Chugai Pharmaceutical Co., Ltd. |
| Reports | - |
| Evaluation Reports | - |
| Other Literatures | List of Submitted Papers ( http://wwwtgp.nibio.go.jp/seika.html , Japanese) - "New Developments in Nutrigenomics, Series 6, Safety Evaluation of Food by Toxicogenomics." Shokuhin to Kaihatsu VOL.42 NO.12. - "Elucidating the Mechanisms of Action of Environmental Chemicals: New Developments in Toxicogenomics - Comparison of 2,3,7,8-TCDD and 2,3,7,8-TCDF by Percellome Project." Saibo Kogaku VOL.26 NO.12. - "Toxicogenomics: Overview of Researches on Chemical Substances Associated with Noncovalent DNA Interaction and Their Potential Applications." Mutat Res. VOL.623 NO.1-2. - Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2002-2006 Comprehensive Research Report. - Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2006 Summary Research Report and Allocated Research Report. - "Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research: Research on Toxicity That Targets Homeostatic Function". Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2005 Summary Research Report and Allocated Research Report. - "Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research: Research on Analysis of Genetic Changes in Precancerous Lesions and Tumors in Colon". Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2005 Summary Research Report and Allocated Research Report. - "Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research: Research on Regulation of Genes Expressed in Kidney by Chemical Substances and Functional Regulation of These Genes". Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2005 Summary Research Report and Allocated Research Report. - "Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research: Research on Developmental Mechanism and Gene Expression Profile of Drug-Induced Liver Lesion in Rat". Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2005 Summary Research Report and Allocated Research Report. - Construction of Safety Prediction System for Drug Development by Toxicogenomics Technology and Related Basic Research. FY2004 Summary Research Report and Allocated Research Report. - "Toxicogenomics Project (3): IT Strategy for Toxicogenomics and Construction of TG-GATEs." Drug Metab Pharmacokinet. VOL.22 NO.3. - Development of Gene Network Analysis Method for Toxicogenomics. FY2006 Summary Research Report. - Development of Gene Network Analysis Method for Toxicogenomics. FY2005 Summary Research Report. - "Toxicogenomics Project (2): Research Strategy." Drug Metab Pharmacokinet. VOL.22 NO.2. - "Toxicogenomics Project (1)." Drug Metab Pharmacokinet. VOL.22 NO.1. - "Toxicogenomics Project." Proceedings of the National Institute of Health Sciences 130th Anniversary Lecture (2004). - "New Initiative in Toxicotranscriptomics in Percellome Project." Saibo Kogaku VOL.26 NO.1. - "Toxicogenomics for More Precise Analysis of Toxicity." Shukan Igaku no Ayumi VOL.218 NO.12. - "Pharmacoinformatics Breaking through the Wall into New Territory: Toxicogenomics - Drug Discovery Technology To Predict Adverse Effects." Yakkyoku VOL.57 NO.6. - "Effects of Difference in Vehicle on Gene Expression during Analysis of Rat Liver in Control Data in Toxicogenomics Project Database." Life Sci. VOL.78 NO.24. - "Prospects for New Drugs 2006, Part 1, Drug Discovery and Drug Nurturing - New Line of Drug Discovery: Progress and Potential of Drug Discovery." Iyaku Journal VOL.42 S-1. - "Biological Response to Environment - Toxicogenomics, Standardization of Technology in Toxicogenomics: Percellome." Igaku no Ayumi VOL.213 NO.4. - "Aims of Toxicogenomics Project." Rinsho Iyaku Vol.21 No.3. - "Pharmacogenomics - From Basic to Clinical: Toxicogenomics Research Efforts in Japan for Drug Development." Gekkan Yakuji VOL.46 NO.6. - "Genomics for Drug Discovery, Proteomics for Drug Discovery and Informatics for Drug Discovery IV, Application to Drug Discovery: Toxicogenomics." Seitai no Kagaku VOL.54 NO.5 - "Medicine in the Age of Post-Genomic Sequence: For New Drug Discovery - Toxicogenomics." Gendai Iryo VOL.35 NO.7. - "Toxicogenomics and Drug Discovery." The Japanese Environmental Mutagen Society Conference Program and Summaries VOL.31. - "Diseases of Mind and Related Fields: Toxicogenomics - Future Prospects." Pharmacia VOL.38 NO.8. |